Academic Journal
Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage
| العنوان: | Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage |
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| المؤلفون: | Pietroboni A. M., Colombi A., Carandini T., Sacchi L., Fenoglio C., Marotta G., Arighi A., De Riz M. A., Fumagalli G. G., Castellani M., Bozzali M., Scarpini E., Galimberti D. |
| المساهمون: | Pietroboni, A. M., Colombi, A., Carandini, T., Sacchi, L., Fenoglio, C., Marotta, G., Arighi, A., De Riz, M. A., Fumagalli, G. G., Castellani, M., Bozzali, M., Scarpini, E., Galimberti, D. |
| سنة النشر: | 2022 |
| المجموعة: | Università degli Studi di Trento: CINECA IRIS |
| مصطلحات موضوعية: | Alzheimer’s disease, amy-PET, Amyloid, Non-AD dementia, White matter |
| الوصف: | Purpose: Positron emission tomography (PET) with amyloid tracers (amy-PET) allows the quantification of pathological amyloid deposition in the brain tissues, including the white matter (WM). Here, we evaluate amy-PET uptake in WM lesions (WML) and in the normal-appearing WM (NAWM) of patients with Alzheimer’s disease (AD) and non-AD type of dementia. Methods: Thirty-three cognitively impaired subjects underwent brain magnetic resonance imaging (MRI), Aβ1-42 (Aβ) determination in the cerebrospinal fluid (CSF) and amy-PET. Twenty-three patients exhibiting concordant results in both CSF analysis and amy-PET for cortical amyloid deposition were recruited and divided into two groups, amyloid positive (A+) and negative (A−). WML quantification and brain volumes’ segmentation were performed. Standardized uptake values ratios (SUVR) were calculated in the grey matter (GM), NAWM and WML on amy-PET coregistered to MRI images. Results: A+ compared to A− showed a higher WML load (p = 0.049) alongside higher SUVR in all brain tissues (p < 0.01). No correlations between CSF Aβ levels and WML and NAWM SUVR were found in A+, while, in A−, CSF Aβ levels were directly correlated to NAWM SUVR (p = 0.04). CSF Aβ concentration was the only predictor of NAWM SUVR (adj R2 = 0.91; p = 0.04) in A−. In A+ but not in A− direct correlations were identified between WM and GM SUVR (p < 0.01). Conclusions: Our data provide evidence on the role of amy-PET in the assessment of microstructural WM injury in non-AD dementia, whereas amy-PET seems less suitable to assess WM damage in AD patients due to a plausible amyloid accrual therein. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35151361; info:eu-repo/semantics/altIdentifier/wos/WOS:000754364300002; volume:14; issue:1; firstpage:331; lastpage:338; numberofpages:8; journal:ALZHEIMER'S RESEARCH & THERAPY; https://hdl.handle.net/11572/355698; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85124622819; https://alzres.biomedcentral.com/articles/10.1186/s13195-021-00933-1#rightslink |
| DOI: | 10.1186/s13195-021-00933-1 |
| DOI: | 10.1186/s13195-021-00933-1#rightslink |
| الاتاحة: | https://hdl.handle.net/11572/355698 https://doi.org/10.1186/s13195-021-00933-1 https://alzres.biomedcentral.com/articles/10.1186/s13195-021-00933-1#rightslink |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B311763A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13195-021-00933-1 |
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