التفاصيل البيبلوغرافية
| العنوان: |
Monthly capillary ketone and glucose variability. |
| المؤلفون: |
Alex Buga, David G. Harper, Teryn N. Sapper, Parker N. Hyde, Brandon Fell, Ryan Dickerson, Justen T. Stoner, Madison L. Kackley, Christopher D. Crabtree, Drew D. Decker, Bradley T. Robinson, Gerald Krystal, Katherine Binzel, Maryam B. Lustberg, Jeff S. Volek |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Biochemistry, Cell Biology, Physiology, Biotechnology, Cancer, Infectious Diseases, Computational Biology, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, maintain nutritional ketosis, hydroxybutyrate (&# 946, fasting capillary βhb, adjuvant therapeutic intervention, sustained metabolic effects, appropriate food daily, 8 mm (<, 7 mm (<, ad libitum <, arm wfkd intervention, mbc undergoing chemotherapy, formulated ketogenic diet, additional three months, improving body composition, >, personalized wfkd, three months (<, fasting plasma glucose, three months, body composition, 5 mm |
| الوصف: |
Purpose Ketogenic diets may positively influence cancer through pleiotropic mechanisms, but only a few small and short-term studies have addressed feasibility and efficacy in cancer patients. The primary goals of this study were to evaluate the feasibility and the sustained metabolic effects of a personalized well-formulated ketogenic diet (WFKD) designed to achieve consistent blood beta-hydroxybutyrate (βHB) >0.5 mM in women diagnosed with stage IV metastatic breast cancer (MBC) undergoing chemotherapy. Methods Women ( n = 20) were enrolled in a six month, two-phase, single-arm WFKD intervention (NCT03535701). Phase I was a highly-supervised, ad libitum , personalized WFKD, where women were provided with ketogenic-appropriate food daily for three months. Phase II transitioned women to a self-administered WFKD with ongoing coaching for an additional three months. Fasting capillary βHB and glucose were collected daily; weight, body composition, plasma insulin, and insulin resistance were collected at baseline, three and six months. Results Capillary βHB indicated women achieved nutritional ketosis (Phase I mean: 0.8 mM ( n = 15); Phase II mean: 0.7 mM ( n = 9)). Body weight decreased 10% after three months, primarily from body fat. Fasting plasma glucose, plasma insulin, and insulin resistance also decreased significantly after three months ( p < 0.01), an effect that persisted at six months. Conclusions Women diagnosed with MBC undergoing chemotherapy can safely achieve and maintain nutritional ketosis, while improving body composition and insulin resistance, out to six months. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Monthly_capillary_ketone_and_glucose_variability_/24930810 |
| DOI: |
10.1371/journal.pone.0296523.t004 |
| الاتاحة: |
https://doi.org/10.1371/journal.pone.0296523.t004
https://figshare.com/articles/dataset/Monthly_capillary_ketone_and_glucose_variability_/24930810 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.B2DCE15 |
| قاعدة البيانات: |
BASE |