Academic Journal
Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine.
| العنوان: | Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine. |
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| المساهمون: | Heo, Dong Nyoung, Yang, Dae Hyeok, Lee, Jung Bok, Bae, Min Soo, Kim, Jung Ho, Moon, Seong Hwan, Chun, Heoung Jae, Kim, Chun Ho, Lim, Ho-Nam, Kwon, Il Keun |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Animals, Burns/drug therapy, Burns/enzymology, Burns/pathology, Cattle, Gelatin/chemistry, Male, Matrix Metalloproteinase 2/metabolism, Matrix Metalloproteinase 9/metabolism, Nanofibers/chemistry, Polyurethanes/chemistry, Rats, Sprague-Dawley, Silver Sulfadiazine/pharmacology, Silver Sulfadiazine/therapeutic use, Tissue Scaffolds/chemistry, Wound Healing*/drug effects, BURN WOUND HEALING, ELECTROSPINNING, PU/GELATIN NANOFIBER SCAFFOLD, SILVER-SULFADIAZINE |
| الوصف: | Despite the fact that advances of burn treatment have led to reduction in the morbidity caused by burns, burn infection is still a serious problem. In this study, we designed blended synthetic and natural polymers nanofiber scaffolds using polyurethane (PU) and gelatin, which were prepared by an electrospinning method. Silver-sulfadiazine (SSD) was co-mixed to the blended polymer solution for being incorporated into the nanofibers after the electrospinning, followed by examination of burn-wound healing effect. The nanofiber scaffolds containing SSD should not only serve as a substrate for skin regeneration, but may also deliver suitable drugs, within a controlled manner during healing. The SSD release was able to prevent the growth of a wide array of bacteria and accelerate the wound healing by preventing infection. Therefore it could accelerate the burn-wound closure rate. We confirmed that PU/gelatin nanofiber scaffolds containing SSD lead to enhanced regeneration of burn-wounds. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1550-7033 1550-7041 |
| Relation: | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY; J01268; OAK-2013-01008; https://ir.ymlib.yonsei.ac.kr/handle/22282913/87126; http://www.ingentaconnect.com/content/asp/jbn/2013/00000009/00000003/art00022; T201301984; JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Vol.9(3) : 511-515, 2013 |
| DOI: | 10.1166/jbn.2013.1509 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87126 https://doi.org/10.1166/jbn.2013.1509 http://www.ingentaconnect.com/content/asp/jbn/2013/00000009/00000003/art00022 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ ; not free |
| رقم الانضمام: | edsbas.B2B9C683 |
| قاعدة البيانات: | BASE |
| تدمد: | 15507033 15507041 |
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| DOI: | 10.1166/jbn.2013.1509 |