Academic Journal
Everolimus-eluting bioresorbable scaffolds and metallic stents in diabetic patients: a patient-level pooled analysis of the prospective ABSORB DM Benelux Study, TWENTE and DUTCH PEERS
| العنوان: | Everolimus-eluting bioresorbable scaffolds and metallic stents in diabetic patients: a patient-level pooled analysis of the prospective ABSORB DM Benelux Study, TWENTE and DUTCH PEERS |
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| المؤلفون: | Hommels, T M, Hermanides, R S, Berta, B, Fabris, E, De Luca, G, Ploumen, E H, von Birgelen, C, Kedhi, E |
| المساهمون: | Hommels, T M, Hermanides, R S, Berta, B, Fabris, E, De Luca, G, Ploumen, E H, von Birgelen, C, Kedhi, E |
| سنة النشر: | 2020 |
| المجموعة: | Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
| مصطلحات موضوعية: | Bioresorbable scaffold, Coronary artery disease, Device thrombosi, Diabetes mellitu, Drug-eluting stent, Percutaneous coronary intervention |
| الوصف: | Background: Several studies compared everolimus-eluting bioresorbable scaffolds (EE-BRS) with everolimus-eluting stents (EES), but only few assessed these devices in patients with diabetes mellitus. Aim: To evaluate the safety and efficacy outcomes of all-comer patients with diabetes mellitus up to 2 years after treatment with EE-BRS or EES. Methods: We performed a post hoc pooled analysis of patient-level data in diabetic patients who were treated with EE-BRS or EES in 3 prospective clinical trials: The ABSORB DM Benelux Study (NTR5447), TWENTE (NTR1256/NCT01066650) and DUTCH PEERS (NTR2413/NCT01331707). Primary endpoint of the analysis was target lesion failure (TLF): a composite of cardiac death, target vessel myocardial infarction or clinically driven target lesion revascularization. Secondary endpoints included major adverse cardiac events (MACE): a composite of all-cause death, any myocardial infarction or clinically driven target vessel revascularization, as well as definite or probable device thrombosis (ST). Results: A total of 499 diabetic patients were assessed, of whom 150 received EE-BRS and 249 received EES. Total available follow-up was 222.6 patient years (PY) in the EE-BRS and 464.9 PY in the EES group. The adverse events rates were similar in both treatment groups for TLF (7.2 vs. 5.2 events per 100 PY, p = 0.39; adjusted hazard ratio (HR) = 1.48 (95% confidence interval (CI): 0.77-2.87), p = 0.24), MACE (9.1 vs. 8.3 per 100 PY, p = 0.83; adjusted HR = 1.23 (95% CI: 0.70-2.17), p = 0.47), and ST (0.9 vs. 0.6 per 100 PY, p > 0.99). Conclusion: In this patient-level pooled analysis of patients with diabetes mellitus from 3 clinical trials, EE-BRS showed clinical outcomes that were quite similar to EES. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33008407; info:eu-repo/semantics/altIdentifier/wos/WOS:000576892200001; volume:19; firstpage:"-"; lastpage:"-"; journal:CARDIOVASCULAR DIABETOLOGY; http://hdl.handle.net/11368/2972783; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85092317062; https://cardiab.biomedcentral.com/articles/10.1186/s12933-020-01116-2 |
| DOI: | 10.1186/s12933-020-01116-2 |
| الاتاحة: | http://hdl.handle.net/11368/2972783 https://doi.org/10.1186/s12933-020-01116-2 https://cardiab.biomedcentral.com/articles/10.1186/s12933-020-01116-2 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B296D35A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12933-020-01116-2 |
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