Academic Journal
Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition
| العنوان: | Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition |
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| المؤلفون: | Franchini, Luca, Stanic, Jennifer, Ponzoni, Luisa, Mellone, Manuela, Carrano, Nicolò, Musardo, Stefano, Zianni, Elisa, Olivero, Guendalina, Marcello, Elena, Pittaluga, Anna, Sala, Mariaelvina, Bellone, Camilla, Racca, Claudia, Di Luca, Monica, Gardoni, Fabrizio |
| المساهمون: | L. Franchini, J. Stanic, L. Ponzoni, M. Mellone, N. Carrano, S. Musardo, E. Zianni, G. Olivero, E. Marcello, A. Pittaluga, M. Sala, C. Bellone, C. Racca, M. Di Luca, F. Gardoni |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2019 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Molecular Interaction, Molecular Neuroscience, Neuroscience, Settore BIO/14 - Farmacologia |
| الوصف: | NMDA receptor (NMDAR) subunit composition plays a pivotal role in synaptic plasticity at excitatory synapses. Still, the mechanisms responsible for the synaptic retention of NMDARs following induction of plasticity need to be fully elucidated. Rabphilin3A (Rph3A) is involved in the stabilization of NMDARs at synapses through the formation of a complex with GluN2A and PSD-95. Here we used different protocols to induce synaptic plasticity in the presence or absence of agents modulating Rph3A function. The use of Forskolin/Rolipram/Picrotoxin cocktail to induce chemical LTP led to synaptic accumulation of Rph3A and formation of synaptic GluN2A/Rph3A complex. Notably, Rph3A silencing or use of peptides interfering with the GluN2A/Rph3A complex blocked LTP induction. Moreover, invivo disruption of GluN2A/Rph3A complex led to a profound alteration of spatial memory. Overall, our results demonstrate a molecular mechanism needed for NMDAR stabilization at synapses after plasticity induction and to trigger downstream signaling events necessary for cognitive behavior. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31518901; info:eu-repo/semantics/altIdentifier/wos/WOS:000488278300079; volume:19; firstpage:927; lastpage:939; numberofpages:13; journal:ISCIENCE; http://hdl.handle.net/2434/675212; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85071907292 |
| DOI: | 10.1016/j.isci.2019.08.036 |
| الاتاحة: | http://hdl.handle.net/2434/675212 https://doi.org/10.1016/j.isci.2019.08.036 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B284EE40 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.isci.2019.08.036 |
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