Academic Journal
أعرض في EDS

Antihypercholesterolemic and Antioxidant Effects of Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets

التفاصيل البيبلوغرافية
العنوان: Antihypercholesterolemic and Antioxidant Effects of Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets
المؤلفون: Widhiantara, I Gede, Permatasari, Anak Agung Ayu Putri, Rosiana, I Wayan, Wiradana, Putu Angga, Widiastini, Luh Putu, Jawi, I Made
المساهمون: Universitas Dhyana Pura and Community Service Institute (LP2M) with Contract Number: 037 / UNDHIRA-LP2M / Lit. / 2020.
المصدر: The Indonesian Biomedical Journal; Vol 13, No 4 (2021); 396-402 ; 2355-9179 ; 2085-3297
بيانات النشر: The Prodia Education and Research Institute (PERI)
سنة النشر: 2021
المجموعة: The Indonesian Biomedical Journal (Prodia Education and Research Institute)
الوصف: BACKGROUND: The discovery of herbal ingredients for antihypercholesterolemic and to improve male reproductive function is very necessary due to high-cholesterol diet factors. Blumea balsamifera leaf extract (BBLE) is known to be able to increase the number and diameter of Leydig cells in rats given high-fat feed. This study was to conducted to determine the levels of total cholesterol, body weight, plasma malondialdehyde (MDA), Superoxide Dismutase (SOD), Luteinizing Hormone (LH) in high-cholesterol-fed male rats provided with BBLE.METHODS: This research utilized a randomized post-test only control group. Ethanol was used to extract the BBLE, which was then evaporated. For 21 days, 16 Wistar rats were given a high-cholesterol diet. To determine the effect of BBLE on the high-cholesterol diet, the samples were divided into two groups (control and BBLE group) on day 22. The treatments lasted 30 days. SOD, plasma MDA, LH, and total cholesterol were measured.RESULTS: The results showed that the SOD and LH parameters were significantly higher in the treatment of BBLE compared to the control group (p<0.05). The parameters of total cholesterol levels, bodyweight, and MDA of rats given BBLE were significantly lower than those of the control group (p<0.05).CONCLUSION: Our findings highlight that BBLE has antihypercholesterolemic and antioxidant effects. The BBLE also has potential to be used as a therapy to maintain male reproductive function because it has a positive effect on the hypothalamic-pituitary axis through increasing LH secretion.KEYWORDS: Malondialdehyde, Superoxide dismutase, Luteinizing hormone, Blumea balsamifera extract, High-cholesterol diet
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
Relation: https://www.inabj.org/index.php/ibj/article/view/1694/556; https://www.inabj.org/index.php/ibj/article/downloadSuppFile/1694/446; https://www.inabj.org/index.php/ibj/article/view/1694
DOI: 10.18585/inabj.v13i4.1694
الاتاحة: https://www.inabj.org/index.php/ibj/article/view/1694
https://doi.org/10.18585/inabj.v13i4.1694
Rights: Copyright (c) 2021 The Prodia Education and Research Institute ; https://creativecommons.org/licenses/by-nc/4.0
رقم الانضمام: edsbas.B27A5FD7
قاعدة البيانات: BASE
ResultId 1
Header edsbas
BASE
edsbas.B27A5FD7
919
3
Academic Journal
academicJournal
918.9462890625
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.B27A5FD7&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://www.inabj.org/index.php/ibj/article/view/1694# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Antihypercholesterolemic and Antioxidant Effects of Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Widhiantara%2C+I+Gede%22&quot;&gt;Widhiantara, I Gede&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Permatasari%2C+Anak+Agung+Ayu+Putri%22&quot;&gt;Permatasari, Anak Agung Ayu Putri&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rosiana%2C+I+Wayan%22&quot;&gt;Rosiana, I Wayan&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wiradana%2C+Putu+Angga%22&quot;&gt;Wiradana, Putu Angga&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Widiastini%2C+Luh+Putu%22&quot;&gt;Widiastini, Luh Putu&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jawi%2C+I+Made%22&quot;&gt;Jawi, I Made&lt;/searchLink&gt; )
Array ( [Name] => Author [Label] => Contributors [Group] => Au [Data] => Universitas Dhyana Pura and Community Service Institute (LP2M) with Contract Number: 037 / UNDHIRA-LP2M / Lit. / 2020. )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => The Indonesian Biomedical Journal; Vol 13, No 4 (2021); 396-402 ; 2355-9179 ; 2085-3297 )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => The Prodia Education and Research Institute (PERI) )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2021 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => The Indonesian Biomedical Journal (Prodia Education and Research Institute) )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => BACKGROUND: The discovery of herbal ingredients for antihypercholesterolemic and to improve male reproductive function is very necessary due to high-cholesterol diet factors. Blumea balsamifera leaf extract (BBLE) is known to be able to increase the number and diameter of Leydig cells in rats given high-fat feed. This study was to conducted to determine the levels of total cholesterol, body weight, plasma malondialdehyde (MDA), Superoxide Dismutase (SOD), Luteinizing Hormone (LH) in high-cholesterol-fed male rats provided with BBLE.METHODS: This research utilized a randomized post-test only control group. Ethanol was used to extract the BBLE, which was then evaporated. For 21 days, 16 Wistar rats were given a high-cholesterol diet. To determine the effect of BBLE on the high-cholesterol diet, the samples were divided into two groups (control and BBLE group) on day 22. The treatments lasted 30 days. SOD, plasma MDA, LH, and total cholesterol were measured.RESULTS: The results showed that the SOD and LH parameters were significantly higher in the treatment of BBLE compared to the control group (p&lt;0.05). The parameters of total cholesterol levels, bodyweight, and MDA of rats given BBLE were significantly lower than those of the control group (p&lt;0.05).CONCLUSION: Our findings highlight that BBLE has antihypercholesterolemic and antioxidant effects. The BBLE also has potential to be used as a therapy to maintain male reproductive function because it has a positive effect on the hypothalamic-pituitary axis through increasing LH secretion.KEYWORDS: Malondialdehyde, Superoxide dismutase, Luteinizing hormone, Blumea balsamifera extract, High-cholesterol diet )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper )
Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => application/pdf )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => https://www.inabj.org/index.php/ibj/article/view/1694/556; https://www.inabj.org/index.php/ibj/article/downloadSuppFile/1694/446; https://www.inabj.org/index.php/ibj/article/view/1694 )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.18585/inabj.v13i4.1694 )
Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://www.inabj.org/index.php/ibj/article/view/1694&lt;br /&gt;https://doi.org/10.18585/inabj.v13i4.1694 )
Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => Copyright (c) 2021 The Prodia Education and Research Institute ; https://creativecommons.org/licenses/by-nc/4.0 )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.B27A5FD7 )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.18585/inabj.v13i4.1694 ) ) [Languages] => Array ( [0] => Array ( [Text] => English ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Antihypercholesterolemic and Antioxidant Effects of Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Widhiantara, I Gede ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Permatasari, Anak Agung Ayu Putri ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Rosiana, I Wayan ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Wiradana, Putu Angga ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Widiastini, Luh Putu ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Jawi, I Made ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Universitas Dhyana Pura and Community Service Institute (LP2M) with Contract Number: 037 / UNDHIRA-LP2M / Lit. / 2020. ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 01 [Type] => published [Y] => 2021 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-locals [Value] => edsbas ) [1] => Array ( [Type] => issn-locals [Value] => edsbas.oa ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => The Indonesian Biomedical Journal; Vol 13, No 4 (2021); 396-402 [Type] => main ) ) ) ) ) ) )
IllustrationInfo