Academic Journal

Antihypercholesterolemic and Antioxidant Effects of Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets

التفاصيل البيبلوغرافية
العنوان: Antihypercholesterolemic and Antioxidant Effects of Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets
المؤلفون: Widhiantara, I Gede, Permatasari, Anak Agung Ayu Putri, Rosiana, I Wayan, Wiradana, Putu Angga, Widiastini, Luh Putu, Jawi, I Made
المساهمون: Universitas Dhyana Pura and Community Service Institute (LP2M) with Contract Number: 037 / UNDHIRA-LP2M / Lit. / 2020.
المصدر: The Indonesian Biomedical Journal; Vol 13, No 4 (2021); 396-402 ; 2355-9179 ; 2085-3297
بيانات النشر: The Prodia Education and Research Institute (PERI)
سنة النشر: 2021
المجموعة: The Indonesian Biomedical Journal (Prodia Education and Research Institute)
الوصف: BACKGROUND: The discovery of herbal ingredients for antihypercholesterolemic and to improve male reproductive function is very necessary due to high-cholesterol diet factors. Blumea balsamifera leaf extract (BBLE) is known to be able to increase the number and diameter of Leydig cells in rats given high-fat feed. This study was to conducted to determine the levels of total cholesterol, body weight, plasma malondialdehyde (MDA), Superoxide Dismutase (SOD), Luteinizing Hormone (LH) in high-cholesterol-fed male rats provided with BBLE.METHODS: This research utilized a randomized post-test only control group. Ethanol was used to extract the BBLE, which was then evaporated. For 21 days, 16 Wistar rats were given a high-cholesterol diet. To determine the effect of BBLE on the high-cholesterol diet, the samples were divided into two groups (control and BBLE group) on day 22. The treatments lasted 30 days. SOD, plasma MDA, LH, and total cholesterol were measured.RESULTS: The results showed that the SOD and LH parameters were significantly higher in the treatment of BBLE compared to the control group (p<0.05). The parameters of total cholesterol levels, bodyweight, and MDA of rats given BBLE were significantly lower than those of the control group (p<0.05).CONCLUSION: Our findings highlight that BBLE has antihypercholesterolemic and antioxidant effects. The BBLE also has potential to be used as a therapy to maintain male reproductive function because it has a positive effect on the hypothalamic-pituitary axis through increasing LH secretion.KEYWORDS: Malondialdehyde, Superoxide dismutase, Luteinizing hormone, Blumea balsamifera extract, High-cholesterol diet
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
Relation: https://www.inabj.org/index.php/ibj/article/view/1694/556; https://www.inabj.org/index.php/ibj/article/downloadSuppFile/1694/446; https://www.inabj.org/index.php/ibj/article/view/1694
DOI: 10.18585/inabj.v13i4.1694
الاتاحة: https://www.inabj.org/index.php/ibj/article/view/1694
https://doi.org/10.18585/inabj.v13i4.1694
Rights: Copyright (c) 2021 The Prodia Education and Research Institute ; https://creativecommons.org/licenses/by-nc/4.0
رقم الانضمام: edsbas.B27A5FD7
قاعدة البيانات: BASE
الوصف
DOI:10.18585/inabj.v13i4.1694