Review
Flunitrazepam-induced changes in neurophysiological, behavioural, and subjective measures used to assess sedation
| العنوان: | Flunitrazepam-induced changes in neurophysiological, behavioural, and subjective measures used to assess sedation |
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| المؤلفون: | Lucchesi, Lígia M. UNIFESP, Pompeia, Sabine UNIFESP, Manzano, Gilberto M. UNIFESP, Kohn, A. F., Galduroz, José CF UNIFESP, Bueno, Orlando FA UNIFESP, Tufik, Sergio UNIFESP |
| المساهمون: | Universidade Federal de São Paulo (UNIFESP), Universidade de São Paulo (USP) |
| بيانات النشر: | Elsevier B.V. |
| سنة النشر: | 2003 |
| المجموعة: | Universidade Federal de São Paulo (UNIFESP): Repositório Institucional |
| مصطلحات موضوعية: | benzodiazepines, EEG, event-related, potentials, ERP, flunitrazepam, P300, sedation |
| الوصف: | Introduction: Certain features of event-related potentials (ERPs), electroencephalographic (EEG), and behavioural measures vary with differing states of alertness and/or sedation. Purpose: This study was conducted to investigate changes in several measures usually viewed as reflecting states of sedation/sleepiness associated with the use of a range of doses of the hypnotic benzodiazepine (BZD) flunitrazepam (FNZ). Methods: This was a double blind, independent group design study of the effects of acute oral doses of FNZ in young healthy volunteers. Forty-eight subjects were randomly allocated to one of four groups-FNZ (0.6, 0.8, and 1.0 mg) and placebo (PLAC)-and tested prior to treatment and then in a posttreatment session close to the theoretical peak plasma concentration. ERP latencies and amplitudes were measured at midfrontal (Fz), midcentral (Cz), and midparietal (Pz) using a standard auditory oddball paradigm. EEG changes were assessed at Pz. Behavioural measures included the digit-symbol substitution test (DSST), a cancellation task (CT), and subjective ratings of alertness and attentiveness by the subjects (SUB) and the experimenter (EXP). Results: FNZ led to psychomotor impairments and decreased alertness and attention; these effects were consistent with previous findings. A progressive, dose-related increase in P3 latency occurred in Fz, Cz, and Pz, and there was an increase in N1 (Fz, Cz) and N2 (Fz). N2-P3 amplitude decreased in Fz. EEG power bands beta 1 increased for the two highest doses, but no significant differences were noted in theta, delta, and alpha bands. P3 latencies, experimenter-rated levels of alertness, and DSST scores differentiated all three doses of FNZ from PLAC. Conclusion: the most sensitive measures used were P3 latencies of the ERPs (which varied with FNZ dose), DSST, and the experimenter-rated levels of alertness. However, we found no evidence for the assumption that one single phenomenon was reflected in all measures and different mechanisms were probably involved. Further ... |
| نوع الوثيقة: | review |
| وصف الملف: | 525-533 |
| اللغة: | English |
| تدمد: | 0278-5846 |
| Relation: | Progress in Neuro-psychopharmacology & Biological Psychiatry; http://dx.doi.org/10.1016/S0278-5846(03)00044-7; Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 27, n. 3, p. 525-533, 2003.; http://repositorio.unifesp.br/handle/11600/27235; WOS:000182462600022 |
| DOI: | 10.1016/S0278-5846(03)00044-7 |
| الاتاحة: | http://repositorio.unifesp.br/handle/11600/27235 https://doi.org/10.1016/S0278-5846(03)00044-7 |
| Rights: | Acesso restrito ; http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
| رقم الانضمام: | edsbas.B264D446 |
| قاعدة البيانات: | BASE |
| تدمد: | 02785846 |
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| DOI: | 10.1016/S0278-5846(03)00044-7 |