Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort.

التفاصيل البيبلوغرافية
العنوان:	Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort.
المؤلفون:	Urowitz, M B, Gladman, D D, Anderson, N M, Su, J, Romero-Diaz, J, Bae, S C, Fortin, P R, Sanchez-Guerrero, J, Clarke, A, Bernatsky, S, Gordon, C, Hanly, J G, Wallace, D J, Isenberg, D, Rahman, A, Merrill, J, Ginzler, E, Alarcón, G S, Fessler, B F, Petri, M, Bruce, I N, Khamashta, M, Aranow, C, Dooley, M, Manzi, S, Ramsey-Goldman, R, Sturfelt, G, Nived, O, Steinsson, K, Zoma, A, Ruiz-Irastorza, G, Lim, S, Kalunian, K C, Ỉnanç, M, van Vollenhoven, R, Ramos-Casals, M, Kamen, D L, Jacobsen, S, Peschken, C, Askanase, A, Stoll, T
المساهمون:	1Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto , Toronto Ontario , Canada. 2Instituto Nacional de Ciencias Medicas y Nutrición , Mexico City , Mexico. 3Department of Rheumatology , Hanyang University Hospital for Rheumatic Diseases , Seoul , Korea. 4Division of Rheumatology , Centre Hospitalier Universitaire de Québec et Université Laval , Quebec City , Canada. 5Division of Rheumatology , Cumming School of Medicine University of Calgary , Calgary, Alberta , Canada. 6Divisions of Clinical Immunology/Allergy and Clinical Epidemiology , Montreal General Hospital, McGill University Health Centre , Montreal, Quebec , Canada. 7Rheumatology Research Group , School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham , Birmingham , UK. 8Division of Rheumatology, Department of Medicine and Department of Pathology , Queen Elizabeth II Health Sciences Centre and Dalhousie University , Halifax, Nova Scotia , Canada. 9Cedars-Sinai/David Geffen School of Medicine at UCLA , Los Angeles, California , USA. 10Centre for Rheumatology Research, University College , London , UK. 11Department of Clinical Pharmacology , Oklahoma Medical Research Foundation , Oklahoma City, Oklahoma , USA. 12Department of Medicine , SUNY Downstate Medical Center , Brooklyn, New York , USA. 13Department of Medicine, Division of Clinical Immunology and Rheumatology , University of Alabama at Birmingham , Birmingham, Alabama , USA. 14Department of Rheumatology , Johns Hopkins University School of Medicine , Baltimore, Maryland , USA. 15Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, London, UK. 16Lupus Research Unit , The Rayne Institute, St Thomas' Hospital, King's College London School of Medicine , London , UK. 17Feinstein Institute for Medical Research , Manhasset, New York , USA. 18Division of Rheumatology and Immunology, Department of Medicine , University of North Carolina , Chapel Hill, North Carolina , USA. 19Department of Medicine , West Penn Allegheny , Pittsburgh, Pennsylvania , USA. 20Northwestern University and Feinberg School of Medicine , Chicago, Illinois , USA. 21Department of Rheumatology , University Hospital Lund , Lund , Sweden. 22Department of Rheumatology , Center for Rheumatology Research Fossvogur Landspitali University Hospital , Reyjkavik , Iceland. 23Lanarkshire Centre for Rheumatology, Hairmyres Hospital , East Kilbride, Scotland , UK. 24Autoimmune Disease Unit, Department of Internal Medicine , Hospital Universitario Cruces., University of the Basque Country , Barakaldo , Spain. 25Division of Rheumatology, Emory University School of Medicine , Atlanta, Georgia , USA. 26UCSD School of Medicine , La Jolla, California , USA. 27Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty , Istanbul University , Istanbul , Turkey. 28Unit for Clinical Therapy Research (ClinTRID), The Karolinska Institute , Stockholm , Sweden. 29Josep Font Autoimmune Diseases Laboratory, IDIBAPS, Department of Autoimmune Diseases , Hospital Clínic , Barcelona , Spain. 30Division of Rheumatology, Medical University of South Carolina , Charleston, South Carolina , USA. 31Department of Rheumatology Rigshospitalet , Copenhagen University Hospital , Copenhagen , Denmark. 32Department of Medicine and Community Health Sciences, University of Manitoba , Winnipeg, Manitoba , Canada. 33Division of Rheumatology, Columbia University Medical Center , New York , USA. 34Department of Rheumatology , Kantousspital , Schaffhausen , Switzerland.
بيانات النشر:	BMJ
سنة النشر:	2016
المجموعة:	Hirsla - Landspítali University Hospital research archive
مصطلحات موضوعية:	Rauðir úlfar, Hjarta- og æðasjúkdómar, Bólgur, RHE12, Cardiovascular Diseases, Inflammation, Lupus Erythematosus, Systemic
الوصف:	To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. ; To describe the frequency of myocardial infarction (MI) prior to the diagnosis of systemic lupus erythematosus (SLE) and within the first 2 years of follow-up. ; The systemic lupus international collaborating clinics (SLICC) atherosclerosis inception cohort enters patients within 15 months of SLE diagnosis. MIs were reported and attributed on a specialised vascular event form. MIs were confirmed by one or more of the following: abnormal ECG, typical or atypical symptoms with ECG abnormalities and elevated enzymes (≥2 times upper limit of normal), or abnormal stress test, echocardiogram, nuclear scan or angiogram. Descriptive statistics were used. ; 31 of 1848 patients who entered the cohort had an MI. Of those, 23 patients had an MI prior to SLE diagnosis or within the first 2 years of disease. Of the 23 patients studied, 60.9% were female, 78.3% were Caucasian, 8.7% black, 8.7% Hispanic and 4.3% other. The mean age at SLE diagnosis was 52.5±15.0 years. Of the 23 MIs that occurred, 16 MIs occurred at a mean of 6.1±7.0 years prior to diagnosis and 7 occurred within the first 2 years of follow-up. Risk factors associated with early MI in univariate analysis are male sex, Caucasian, older age at diagnosis, hypertension, hypercholesterolaemia, family history of MI and smoking. In multivariate analysis only age (OR=1.06 95% CI 1.03 to 1.09), hypertension (OR=5.01, 95% CI 1.38 to 18.23), hypercholesterolaemia (OR=4.43, 95% CI 1.51 to 12.99) and smoking (OR=7.50, 95% CI 2.38 to 23.57) remained significant risk factors. ; In some patients with lupus, MI may develop even before the diagnosis of SLE or shortly thereafter, suggesting that there may be a link between autoimmune inflammation and atherosclerosis.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
تدمد:	2053-8790
Relation:	http://dx.doi.org/ 10.1136/lupus-2015-000143; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836282/; Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort. 2016, 3 (1):e000143 Lupus Sci Med; http://hdl.handle.net/2336/618914; Lupus science & medicine
DOI:	10.1136/lupus-2015-000143
الاتاحة:	http://hdl.handle.net/2336/618914 https://doi.org/10.1136/lupus-2015-000143
Rights:	Archived with thanks to Lupus science & medicine ; Open Access
رقم الانضمام:	edsbas.B25C25B6
قاعدة البيانات:	BASE

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الوصف
تدمد:	20538790
DOI:	10.1136/lupus-2015-000143