التفاصيل البيبلوغرافية
| العنوان: |
Doxorubicin-Conjugated Iron Oxide Nanoparticles Synthesized by Laser Pyrolysis: In Vitro Study on Human Breast Cancer Cells |
| المؤلفون: |
Iulia Ioana Lungu, Simona Nistorescu, Mădălina Andreea Badea, Andreea-Mihaela Petre, Ana-Maria Udrea, Ana-Maria Banici, Claudiu Fleacă, Ecaterina Andronescu, Anca Dinischiotu, Florian Dumitrache, Angela Staicu, Mihaela Balaș |
| المصدر: |
Polymers; Volume 12; Issue 12; Pages: 2799 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2020 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
drug delivery, iron oxide nanoparticles, doxorubicin, breast human cells, in vitro cytotoxicity |
| الوصف: |
Even today, breast cancer remains a global public problem, with a high mortality rate among women. Nanoparticle (NP) based systems are developed to enhance drug delivery, reducing the toxic effect of medicine molecules. By using iron oxide nanoparticles for cancer treatment, several advantages were highlighted: the ability to target specific locations derived from their magnetic properties and reduced side effects. The aim of this study was to examine on breast cancer cell line the anticancer potential of γ-Fe2O3 NPs loaded with doxorubicin (DOX) and stabilized with carboxymethylcellulose sodium (CMCNa). The γ-Fe2O3 NPs were synthesized by laser pyrolysis technique and their nanometric size and crystallinity were confirmed by X-ray diffraction and transmission electron microscopy. The loading efficiency was estimated by using absorption and fluorescence spectroscopy. The DOX conjugated//CMCNa coated γ-Fe2O3 NPs proved through the biological studies to have a good anticancer effect through the inhibition of tumoral cell proliferation, disruption of the cellular membrane, induction of cell death and reduced effects on normal breast cells. Our data showed that DOX cytotoxicity increases significantly when conjugated with ɣ-Fe2O3 and ɣ-Fe2O3_CMCNa, a 50% reduction of cancer cell viability was obtained with a concentration around 0.1 µg/mL. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Polymer Applications; https://dx.doi.org/10.3390/polym12122799 |
| DOI: |
10.3390/polym12122799 |
| الاتاحة: |
https://doi.org/10.3390/polym12122799 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.B255C15D |
| قاعدة البيانات: |
BASE |