Academic Journal
Sex Differences in Pain and Quantitative Sensory Testing in Patients With Rheumatoid Arthritis
| العنوان: | Sex Differences in Pain and Quantitative Sensory Testing in Patients With Rheumatoid Arthritis |
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| المؤلفون: | Vogel, Kelly, Muhammad, Lutfiyya N., Song, Jing, Neogi, Tuhina, Bingham, Clifton O., Bolster, Marcy B., Marder, Wendy, Wohlfahrt, Alyssa, Clauw, Daniel J., Dunlop, Dorothy, Lee, Yvonne C. |
| المساهمون: | National Institute of Arthritis and Musculoskeletal and Skin Diseases |
| المصدر: | Arthritis Care & Research ; volume 75, issue 12, page 2472-2480 ; ISSN 2151-464X 2151-4658 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Objective Women with rheumatoid arthritis (RA) have higher pain and worse functional outcomes compared to men, even when treated with similar medications. The objective of this study was to identify sex differences in pain intensity, pain interference, and quantitative sensory tests (QST), which are independent of inflammation, in patients with RA. Methods This study is a post hoc analysis of participants in the Central Pain in Rheumatoid Arthritis cohort. Pain intensity was assessed using a 0–10 numeric rating scale. Pain interference was measured using a Patient‐Reported Outcomes Measurement Information System computerized adaptive test. QST included pressure pain detection thresholds, temporal summation, and conditioned pain modulation. Women and men were compared using multiple linear regression, adjusted for age, education, race, research site, depression, obesity, RA disease duration, swollen joint count, and C‐reactive protein. Results Mean ± SD pain intensity was 5.32 ± 2.29 among women with RA, compared to 4.60 ± 2.23 among men with RA (adjusted difference 0.83 [95% confidence interval (95% CI) 0.14, 1.53]). Women with RA had lower pressure pain detection thresholds at the trapezius (adjusted difference –1.22 [95% CI –1.73, –0.72]), wrist (adjusted difference –0.57 [95% CI –1.07, –0.06]), and knee (adjusted difference –1.10 [95% CI –2.00, –0.21]). No statistically significant differences in pain interference, temporal summation, and conditioned pain modulation were observed. Conclusion Women reported higher pain intensity and lower pressure pain detection thresholds (higher pain sensitivity) than men. However, pain interference, temporal summation, and conditioned pain modulation did not differ between men and women. image |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/acr.25178 |
| الاتاحة: | http://dx.doi.org/10.1002/acr.25178 https://onlinelibrary.wiley.com/doi/pdf/10.1002/acr.25178 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.B1D24E06 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/acr.25178 |
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