التفاصيل البيبلوغرافية
| العنوان: |
Clinical correlates of a subset of anti-fibroblast antibodies in systemic sclerosis |
| المؤلفون: |
Elvira Favoino, Paola Cipriani, Vasiliki Liakouli, Addolorata Corrado, Luca Navarini, Marta Vomero, Adriana Sisto, Rosa Daniela Grembiale, Francesco Ciccia, Francesco P Cantatore, Piero Ruscitti, Roberto Giacomelli, Federico Perosa |
| المساهمون: |
Favoino, Elvira, Cipriani, Paola, Liakouli, Vasiliki, Corrado, Addolorata, Navarini, Luca, Vomero, Marta, Sisto, Adriana, Daniela Grembiale, Rosa, Ciccia, Francesco, P Cantatore, Francesco, Ruscitti, Piero, Giacomelli, Roberto, Perosa, Federico |
| سنة النشر: |
2023 |
| المجموعة: |
Università degli Studi di Bari Aldo Moro: CINECA IRIS |
| مصطلحات موضوعية: |
Anti-fibroblast antibodie, Interstitial lung disease, Peptide, Systemic sclerosis |
| الوصف: |
Anti-fibroblast antibodies (AFA) have been reported in systemic sclerosis (SSc) and are known to promote fibroblast activation. Aim of this study was to characterize the fine specificity of AFA and to analyze any correlations with clinical parameters associated to fibrosis. To this end, AFA were affinity-purified from a patient with diffuse cutaneous SSc (dcSSc) and interstitial lung disease (ILD). Panning of a phage display peptide library with purified AFA identified the motif . The peptide p121, bearing the AFA-specific motif, was used in ELISA to screen sera from 186 SSc patients and 81 healthy donors. Anti-p121 Ab serum levels were statistically higher in SSc than in healthy groups, and directly associated with dcSSc, reduced FVC (FVC < 70), and ILD. Given these clinical correlates, this study lays the groundwork for the identification of the antigen recognized by anti-p121 Ab, which might represent a novel therapeutic target for ILD. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:001072408800001; journal:CLINICAL IMMUNOLOGY; https://hdl.handle.net/11586/447680; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85168938484 |
| الاتاحة: |
https://hdl.handle.net/11586/447680 |
| رقم الانضمام: |
edsbas.B1B0BF97 |
| قاعدة البيانات: |
BASE |