Academic Journal
Light and heavy ferritin chain expression in the liver and kidneys of Wistar rats: aging, sex differences, and impact of gonadectomy
| العنوان: | Light and heavy ferritin chain expression in the liver and kidneys of Wistar rats: aging, sex differences, and impact of gonadectomy |
|---|---|
| المؤلفون: | Vulinović Mirela Pavić, Turčić Petra, Micek Vedran, Ljubojević Marija |
| المصدر: | Arhiv za Higijenu Rada i Toksikologiju, Vol 73, Iss 1, Pp 48-61 (2022) |
| بيانات النشر: | Sciendo |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | ferritin nanocage, hepatocytes, immunofluorescence, intercalated cells, iron metabolism, macula densa, nephron, steroid hormones, western blot, epitelne stanice, feritinski nanokavez, hepatociti, imunofluorescencija, interkalirane stanice, metabolizam željeza, nefron, steroidni hormoni, Toxicology. Poisons, RA1190-1270 |
| الوصف: | Ferritin is the main intracellular storage of iron. Animal studies show that female liver and kidney express more ferritin and accumulate more iron than male. However, no study so far has investigated sex and age differences in light (FtL) and heavy (FtH) ferritin chain expression. To address this, we relied on specific antibodies and immunochemical methods to analyse the expression of both ferritin chains in the liver and kidney of 3-month and 2-year-old male and female Wistar rats. To see how sex hormones may affect expression we also studied adult animals gonadectomised at the age of 10 weeks. FtL and FtH were more expressed in both organs of female rats, while gonadectomy increased the expression in males and decreased it in females, which suggests that it is stimulated by female and inhibited by male steroid hormones. Normal kidney ferritin distribution and change with aging warrant more attention in studies of (patho) physiological and toxicological processes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English Croatian |
| تدمد: | 1848-6312 |
| Relation: | https://doi.org/10.2478/aiht-2022-73-3621; https://doaj.org/toc/1848-6312; https://doaj.org/article/041a9fc68ffe49f285352a9d29de9441 |
| DOI: | 10.2478/aiht-2022-73-3621 |
| الاتاحة: | https://doi.org/10.2478/aiht-2022-73-3621 https://doaj.org/article/041a9fc68ffe49f285352a9d29de9441 |
| رقم الانضمام: | edsbas.B1B06B7C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 18486312 |
|---|---|
| DOI: | 10.2478/aiht-2022-73-3621 |