Academic Journal
Virologic response and characterisation of HCV genotype 2-6 in patients receiving TMC435 monotherapy (study TMC435-C202).
| العنوان: | Virologic response and characterisation of HCV genotype 2-6 in patients receiving TMC435 monotherapy (study TMC435-C202). |
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| المؤلفون: | Lenz, Oliver, Vijgen, Leen, Berke, Jan Martin, Cummings, Maxwell D, Fevery, Bart, Peeters, Monika P., De Smedt, Goedele, Moreno, Christophe, Picchio, Gaston |
| المصدر: | Journal of hepatology, 58 (3 |
| سنة النشر: | 2013 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Sciences bio-médicales et agricoles, Antiviral Agents -- therapeutic use, Genotype, Hepacivirus -- classification -- drug effects -- genetics, Hepatitis C -- drug therapy -- virology, Heterocyclic Compounds, 3-Ring -- pharmacology -- therapeutic use, Humans, Mutation, Polymorphism, Genetic, RNA, Viral -- blood, Sulfonamides -- pharmacology -- therapeutic use, Viral Nonstructural Proteins -- antagonists & inhibitors -- genetics |
| الوصف: | TMC435 is a potent, once-daily, investigational hepatitis C virus (HCV) NS3/4A protease inhibitor in phase III clinical development. In the phase II trial TMC435-C202 (NCT00812331), TMC435 displayed potent activity in genotype 4, 5 and 6 patients and in 3/6 genotype 2 patients, whereas no activity was observed with genotype 3. ; Journal Article ; Research Support, Non-U.S. Gov't ; SCOPUS: ar.j ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| Relation: | uri/info:doi/10.1016/j.jhep.2012.10.028; uri/info:pii/S0168-8278(12)00829-X; uri/info:pmid/23142061; uri/info:scp/84874105854; https://dipot.ulb.ac.be/dspace/bitstream/2013/156155/3/Elsevier_141070.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/156155 |
| الاتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/156155 https://dipot.ulb.ac.be/dspace/bitstream/2013/156155/3/Elsevier_141070.pdf |
| رقم الانضمام: | edsbas.B1A163CE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |