التفاصيل البيبلوغرافية
| العنوان: |
A new function of the Fas-FasL pathway in macrophage activation |
| المؤلفون: |
Chakour, Reza, Allenbach, Cindy, Desgranges, Florian, Charmoy, Mélanie, Mauel, Jacques, Garcia, Irène, Launois, Pascal, Louis, Jacques, Tacchini-Cottier, Fabienne |
| المصدر: |
ISSN: 0741-5400 ; Journal of leukocyte biology, vol. 86, no. 1 (2009) p. 81-90. |
| سنة النشر: |
2009 |
| المجموعة: |
Université de Genève: Archive ouverte UNIGE |
| مصطلحات موضوعية: |
info:eu-repo/classification/ddc/616.07, Animals, Antigens, CD95/metabolism, Fas Ligand Protein/pharmacology, Interferon-gamma/pharmacology, Interleukin-4/pharmacology, Leishmania major/immunology, Macrophage Activation, Macrophages/parasitology/secretion, Mice, Inbred BALB C, Signal Transduction/immunology |
| الوصف: |
Upon infection with the protozoan parasite Leishmania major, susceptible BALB/c mice develop unhealing lesions associated with the maturation of CD4(+)Th2 cells secreting IL-4. In contrast, resistant C57BL/6 mice heal their lesions, because of expansion and secretion of IFN-gamma of CD4(+) Th1 cells. The Fas-FasL pathway, although not involved in Th cell differentiation, was reported to be necessary for complete resolution of lesions. We investigate here the role of IFN-gamma and IL-4 on Fas-FasL nonapoptotic signaling events leading to the modulation of macrophage activation. We show that addition of FasL and IFN-gamma to BMMø led to their increased activation, as reflected by enhanced secretion of TNF, IL-6, NO, and the induction of their microbicidal activity, resulting in the killing of intracellular L. major. In contrast, the presence of IL-4 decreased the synergy of IFN-gamma/FasL significantly on macrophage activation and the killing of intracellular L. major. These results show that FasL synergizes with IFN-gamma to activate macrophages and that the tight regulation by IFN-gamma and/or IL-4 of the nonapoptotic signaling events triggered by the Fas-FasL pathway affects significantly the activation of macrophages to a microbicidal state and may thus contribute to the pathogenesis of L. major infection. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/19380712; https://archive-ouverte.unige.ch/unige:5459; unige:5459 |
| الاتاحة: |
https://archive-ouverte.unige.ch/unige:5459 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: |
edsbas.B18366B4 |
| قاعدة البيانات: |
BASE |