Academic Journal
Outcomes of SARS-CoV-2 infection in 126 children and adolescents with central nervous system tumors
| العنوان: | Outcomes of SARS-CoV-2 infection in 126 children and adolescents with central nervous system tumors |
|---|---|
| المؤلفون: | Moreira, Daniel C, Qaddoumi, Ibrahim, Chen, Yichen, Bhakta, Nickhill, Chantada, Guillermo L, Santana, Victor M, Caniza, Miguela A, Devidas, Meenakshi, Pritchard-Jones, Kathy, Rodriguez-Galindo, Carlos, Bouffet, Eric, Mukkada, Sheena, Global Registry of COVID-19 in Childhood Cancer |
| المصدر: | Pediatric Blood and Cancer , 70 (8) , Article e30402. (2023) |
| بيانات النشر: | Wiley-Blackwell |
| سنة النشر: | 2023 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Global Registry of COVID-19 in Childhood Cancer |
| الوصف: | BACKGROUND: The Global Registry of COVID-19 in Childhood Cancer (GRCCC) seeks to describe the natural history of SARS-CoV-2 in children with cancer across the world. Here, we report the disease course and management of coronavirus disease 2019 (COVID-19) infection in the subset of children and adolescents with central nervous system (CNS) tumors who were included in the GRCCC until February 2021, the first data freeze. PROCEDURE: The GRCCC is a deidentified web-based registry of patients less than 19 years of age with cancer or recipients of a hematopoietic stem cell transplant and laboratory-confirmed SARS-CoV-2 infection. Demographic data, cancer diagnosis, cancer-directed therapy, and clinical characteristics of SARS-CoV-2 infection were collected. Outcomes were collected at 30 and 60 days post infection. RESULTS: The GRCCC included 1500 cases from 45 countries, including 126 children with CNS tumors (8.4%). Sixty percent of the cases were from middle-income countries, while no cases were reported from low-income countries. Low-grade gliomas, high-grade gliomas, and CNS embryonal tumors were the most common CNS cancer diagnoses (67%, 84/126). Follow-up at 30 days was available for 107 (85%) patients. Based on the composite measure of severity, 53.3% (57/107) of reported SARS-CoV-2 infections were asymptomatic, 39.3% (42/107) were mild/moderate, and 6.5% (7/107) were severe or critical. One patient died from SARS-CoV-2 infection. There was a significant association between infection severity and absolute neutrophil count less than 500 (p = .04). Of 107 patients with follow-up available, 40 patients (37.4%) were not receiving cancer-directed therapy. Thirty-four patients (50.7%) had a modification to their treatment due to withholding of chemotherapy or delays in radiotherapy or surgery. CONCLUSION: In this cohort of patients with CNS tumors and COVID-19, the frequency of severe infection appears to be low, although severe disease and death do occur. We found that greater severity was seen in patients with ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10170903/5/Pritchard-Jones_COVID%20CNS%20Manuscript%20R2%20accepted.pdf; https://discovery.ucl.ac.uk/id/eprint/10170903/6/Pritchard-Jones_COVID%20CNS%20Tables%20Fig%20v4.0%20accepted.pdf; https://discovery.ucl.ac.uk/id/eprint/10170903/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10170903/5/Pritchard-Jones_COVID%20CNS%20Manuscript%20R2%20accepted.pdf https://discovery.ucl.ac.uk/id/eprint/10170903/6/Pritchard-Jones_COVID%20CNS%20Tables%20Fig%20v4.0%20accepted.pdf https://discovery.ucl.ac.uk/id/eprint/10170903/ |
| Rights: | open |
| رقم الانضمام: | edsbas.B179D22B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |