التفاصيل البيبلوغرافية
| العنوان: |
Combined Immune Defect in B-Cell Lymphoproliferative Disorders Is Associated with Severe Infection and Cancer Progression |
| المؤلفون: |
Juliana Ochoa-Grullón, Kissy Guevara-Hoyer, Cristina Pérez López, Rebeca Pérez de Diego, Ascensión Peña Cortijo, Marta Polo, Marta Mateo Morales, Eduardo Anguita Mandley, Carlos Jiménez García, Estefanía Bolaños, Belén Íñigo, Fiorella Medina, Antonia Rodríguez de la Peña, Carmen Izquierdo Delgado, Eduardo de la Fuente Muñoz, Elsa Mayol, Miguel Fernández-Arquero, Ataúlfo González-Fernández, Celina Benavente Cuesta, Silvia Sánchez-Ramón |
| المصدر: |
Biomedicines; Volume 10; Issue 8; Pages: 2020 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
B cell chronic lymphoproliferative disorders, severe infections, secondary immunodeficiency, predominantly antibody defect, combine immune defect, cancer progression |
| الوصف: |
B cell chronic lymphoproliferative diseases (B-CLPD) are associated with secondary antibody deficiency and other innate and adaptive immune defects, whose impact on infectious risk has not been systematically addressed. We performed an immunological analysis of a cohort of 83 B-CLPD patients with recurrent and/or severe infections to ascertain the clinical relevance of the immune deficiency expression. B-cell defects were present in all patients. Patients with combined immune defect had a 3.69-fold higher risk for severe infection (p = 0.001) than those with predominantly antibody defect. Interestingly, by Kaplan–Meier analysis, combined immune defect showed an earlier progression of cancer with a hazard ratio of 3.21, than predominantly antibody defect (p = 0.005). When B-CLPD were classified in low-degree, high-degree, and plasma cell dyscrasias, risk of severe disease and cancer progression significantly diverged in combined immune defect, compared with predominantly antibody defect (p = 0.001). Remarkably, an underlying primary immunodeficiency (PID) was suspected in 12 patients (14%), due to prior history of infections, autoimmune and granulomatous conditions, atypical or variegated course and compatible biological data. This first proposed SID classification might have relevant clinical implications, in terms of predicting severe infections and cancer progression, and might be applied to different B-CLPD entities. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Immunology and Immunotherapy; https://dx.doi.org/10.3390/biomedicines10082020 |
| DOI: |
10.3390/biomedicines10082020 |
| الاتاحة: |
https://doi.org/10.3390/biomedicines10082020 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.B1686FBA |
| قاعدة البيانات: |
BASE |