Academic Journal
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response
| العنوان: | IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response |
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| المؤلفون: | Núñez, Felipe J., Mendez, Flor M., Kadiyala, Padma, Alghamri, Mahmoud S., Savelieff, Masha G., Garcia-Fabiani, Maria B., Haase, Santiago, Koschmann, Carl, Calinescu, Anda-Alexandra, Kamran, Neha, Saxena, Meghna, Patel, Rohin, Carney, Stephen, Guo, Marissa Z., Edwards, Marta, Ljungman, Mats, Qin, Tingting, Sartor, Maureen A., Tagett, Rebecca, Venneti, Sriram, Brosnan-Cashman, Jacqueline, Meeker, Alan, Gorbunova, Vera, Zhao, Lili, Kremer, Daniel M., Zhang, Li, Lyssiotis, Costas A., Jones, Lindsey, Herting, Cameron J., Ross, James L., Hambardzumyan, Dolores, Hervey-Jumper, Shawn, Figueroa, Maria E., Lowenstein, Pedro R., Castro, Maria G. |
| المساهمون: | National Institutes of Health, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering |
| المصدر: | Science Translational Medicine ; volume 11, issue 479 ; ISSN 1946-6234 1946-6242 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS) |
| سنة النشر: | 2019 |
| الوصف: | Mutant IDH1 coexpressed with inactivating TP53 and ATRX mutations in glioma enhances DNA repair, causing resistance to genotoxic therapies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1126/scitranslmed.aaq1427 |
| الاتاحة: | https://doi.org/10.1126/scitranslmed.aaq1427 https://syndication.highwire.org/content/doi/10.1126/scitranslmed.aaq1427 https://www.science.org/doi/pdf/10.1126/scitranslmed.aaq1427 |
| رقم الانضمام: | edsbas.B1361EB7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/scitranslmed.aaq1427 |
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