Academic Journal
Long-term macrolide therapy in chronic inflammatory airway diseases
| العنوان: | Long-term macrolide therapy in chronic inflammatory airway diseases |
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| المؤلفون: | Crosbie, P. A J, Woodhead, M. A. |
| المصدر: | Crosbie , P A J & Woodhead , M A 2009 , ' Long-term macrolide therapy in chronic inflammatory airway diseases ' , European Respiratory Journal , vol. 33 , no. 1 , pp. 171-181 . https://doi.org/10.1183/09031936.00042208 |
| سنة النشر: | 2009 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| مصطلحات موضوعية: | Airway, Anti-inflammatory, Ketolide, Macrolide |
| الوصف: | In addition to direct antibacterial actions, 14- and 15-member-ring macrolides have immune modulating effects that appear to be the reason for clinical benefit in diffuse panbronchiolitis. A literature search was conducted for studies of the clinical effectiveness of macrolides in other chronic lung conditions. A number of studies were identified that showed short-term beneficial outcomes or the potential for such outcomes in cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, asthma and post-transplant obliterative bronchiolitis. The studies were limited by small patient numbers, different outcome measures and short-term follow-up, and were not designed to assess potentially harmful effects. Further large prospective and long-term studies are required in order to identify potential benefit and harm before these agents can be recommended routinely for these conditions. Copyright©ERS Journals Ltd 2009. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1183/09031936.00042208 |
| الاتاحة: | https://research.manchester.ac.uk/en/publications/d539cb11-7db4-43a9-b614-2cee2d62cde5 https://doi.org/10.1183/09031936.00042208 http://erj.ersjournals.com/cgi/reprint/33/1/171 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.B128EBC7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1183/09031936.00042208 |
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