Academic Journal
Clinical influence of neoadjuvant chemoradiotherapy on immunonutritional status in locally advanced rectal cancer
| العنوان: | Clinical influence of neoadjuvant chemoradiotherapy on immunonutritional status in locally advanced rectal cancer |
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| المؤلفون: | Soohyeon Lee, Dong Hyun Kang, Tae Sung Ahn, Dong Hee Jo, Eunhyeon Kim, Moo Jun Baek |
| المصدر: | Korean Journal of Clinical Oncology, Vol 19, Iss 1, Pp 3-10 (2023) |
| بيانات النشر: | Korean Society of Surgical Oncology |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | rectal neoplasms, chemoradiotherapy, nutritional status, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Surgery, RD1-811 |
| الوصف: | Purpose Cancer patients receiving various anti-cancer treatments commonly experience malnutrition, and many studies have reported that nutritional status is associated with survival and prognosis. Although standard neoadjuvant chemoradiotherapy (CRT) is commonly used in patients with locally advanced rectal cancer owing to its tumor-downsizing and downstaging effects, there is a lack of research on the impact of patients’ nutritional status on the efficacy of neoadjuvant CRT. Methods We investigated the immunonutritional markers before and after long-course neoadjuvant CRT in 131 patients diagnosed with locally advanced rectal cancer from March 2013 to March 2022. Results We divided the patients into two groups: a low prognostic nutritional index (PNI) with a cutoff value of 50.92, and a high PNI. In both groups, significant decreases in lymphocyte count and PNI and an increase in neutrophil-to-lymphocyte ratio (NLR) were observed before and after CRT (P<0.001). Furthermore, a higher proportion of patients experienced adverse effects in the low PNI group than in the high PNI group (76.6% in low PNI vs. 54.8% in high PNI, P=0.013). The most commonly reported CRT-induced adverse effect was lower gastrointestinal tract toxicity. Conclusion By measuring the PNI and NLR without additional tests prior to starting neoadjuvant CRT in patients with locally advanced rectal cancer, it is possible to predict the risk of acute adverse effects caused by CRT. Additionally, providing external nutritional support to reduce the immunonutritional changes that occur during CRT can decrease side effects and potentially increase treatment compliance. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1738-8082 2288-4084 |
| Relation: | http://www.kjco.org/upload/kjco-19-1-3.pdf; https://doaj.org/toc/1738-8082; https://doaj.org/toc/2288-4084; https://doaj.org/article/7c77fecd97ba41049b6c72849dd4aedb |
| DOI: | 10.14216/kjco.23002 |
| الاتاحة: | https://doi.org/10.14216/kjco.23002 https://doaj.org/article/7c77fecd97ba41049b6c72849dd4aedb |
| رقم الانضمام: | edsbas.B0C7AE9E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17388082 22884084 |
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| DOI: | 10.14216/kjco.23002 |