Academic Journal
The epidemiology of pituitary adenomas in Iceland, 1955-2012: a nationwide population-based study.
| العنوان: | The epidemiology of pituitary adenomas in Iceland, 1955-2012: a nationwide population-based study. |
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| المؤلفون: | Agustsson, Tomas Thor, Baldvinsdottir, Tinna, Jonasson, Jon G, Olafsdottir, Elinborg, Steinthorsdottir, Valgerdur, Sigurdsson, Gunnar, Thorsson, Arni V, Carroll, Paul V, Korbonits, Márta, Benediktsson, Rafn |
| المساهمون: | 1 Landspitali Natl Univ Hosp Iceland, Dept Endocrinol & Metab Med, IS-108 Reykjavik, Iceland, 2 Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland 3 Landspitali Natl Univ Hosp Iceland, Dept Pathol, IS-108 Reykjavik, Iceland 4 Icelandic Canc Registry, IS-105 Reykjavik, Iceland 5 deCODE Genet, IS-101 Reykjavik, Iceland 6 Landspitali Natl Univ Hosp Iceland, Dept Paediat, IS-101 Reykjavik, Iceland 7 Guys & St Thomas NHS Fdn Trust, Dept Endocrinol & Diabet, London SE1 7EH, England 8 Queen Mary Univ London, Barts & London Sch Med, William Harvey Res Inst, Endocrinol, London EC1M 6BQ, England |
| بيانات النشر: | Bioscientifical LTD, Euro House |
| سنة النشر: | 2015 |
| المجموعة: | Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: | Krabbamein, Pituitary Neoplasms/epidemiology, Iceland, Quality of Life, Acromegaly |
| الوصف: | To access publisher's full text version of this article click on the hyperlink at the bottom of the page ; Pituitary adenomas (PA) are among the most common human neoplasms. To describe the epidemiology and assess the disease burden of clinically significant PAs, population-based studies are needed. Iceland has a small well-defined population. The aim of this study is to describe the epidemiology of PAs in Iceland over an expanded period of time. ; This is a retrospective observational study, including all PAs diagnosed in Iceland from 1955 to 2012. ; Extensive clinical information was gathered in a database. Prevalence rates for all PA subtypes were calculated along with standardized incidence rates (SIR). Sex ratios and relationships with adenoma size, age, and symptoms were assessed. ; We identified 471 individuals: 190 men and 281 women. Total prevalence in 2012 was 115.57/100, 000, prolactinomas were most prevalent (54.37/100, 000) followed by non-functioning adenomas (NFPAs) (42.32/100 ,000). Throughout the period, NFPAs were most common (43.0%) followed by prolactinomas (39.9%) and 11.3% had acromegaly and 5.7% Cushing's disease. Women are diagnosed younger with smaller adenomas. Total SIR has increased significantly and is now 5.8/100 000 per year. ; In this nationwide study spanning six decades, we have confirmed PAs rising prevalence and incidence rates noted in recent studies. We demonstrated higher overall prevalence and incidence rates than ever previously recorded with an increasing predominance of NFPAs, which is not explained by incidental findings alone. There is a relationship with the introduction of imaging modalities, but the vast majority of patients are symptomatic at diagnosis. This underlines the importance of increased awareness, education, and appropriate allocation of resources for this growing group of patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1479-683X |
| Relation: | http://dx.doi.org/ 10.1530/EJE-15-0189; The epidemiology of pituitary adenomas in Iceland, 1955-2012: a nationwide population-based study. 2015, 173 (5):655-64 Eur. J. Endocrinol.; http://hdl.handle.net/2336/592763; European journal of endocrinology / European Federation of Endocrine Societies |
| DOI: | 10.1530/EJE-15-0189 |
| الاتاحة: | http://hdl.handle.net/2336/592763 https://doi.org/10.1530/EJE-15-0189 |
| Rights: | Archived with thanks to European journal of endocrinology / European Federation of Endocrine Societies ; Closed - Lokað |
| رقم الانضمام: | edsbas.B0BED2D3 |
| قاعدة البيانات: | BASE |
| تدمد: | 1479683X |
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| DOI: | 10.1530/EJE-15-0189 |