Academic Journal
Risk of embolic events before and after antibiotic treatment initiation among patients with left-side infective endocarditis.
| العنوان: | Risk of embolic events before and after antibiotic treatment initiation among patients with left-side infective endocarditis. |
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| المؤلفون: | Papadimitriou-Olivgeris, M., Guery, B., Ianculescu, N., Auberson, D., Tozzi, P., Kirsch, M., Monney, P. |
| المصدر: | Infection, vol. 52, no. 1, pp. 117-128 |
| سنة النشر: | 2024 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Humans, Staphylococcus aureus, Prospective Studies, Abscess/complications, Endocarditis, Bacterial/diagnosis, Endocarditis/drug therapy, Endocarditis/complications, Risk Factors, Embolism/etiology, Embolism/complications, Sepsis/drug therapy, Anti-Bacterial Agents/therapeutic use, Embolization, Infective endocarditis, Valvular surgery, Vegetation |
| الوصف: | Embolic events (EEs) are a common complication of left-side infective endocarditis (IE). The aim of the present study was to identify risk factors for the occurrence of EEs before or after antibiotic treatment instauration among patients with definite or possible IE. This retro-prospective study was conducted at the Lausanne University Hospital, Lausanne, Switzerland, from January 2014 to June 2022. EEs and IE were defined according to modified Duke criteria. A total of 441 left-side IE episodes were included (334: 76% were definite and 107; 24% possible IE). EE were diagnosed in 260 (59%) episodes; in 190 (43%) before antibiotic treatment initiation and 148 (34%) after. Central nervous system (184; 42%) was the most common site of EE. Multivariable analysis identified S. aureus (P 0.022), immunological phenomena (P < 0.001), sepsis (P 0.027), vegetation size ≥ 10 mm (P 0.003) and intracardiac abscess (P 0.022) as predictors of EEs before antibiotic treatment initiation. For EEs after antibiotic treatment initiation, multivariable analysis revealed vegetation size ≥ 10 mm (P < 0.001), intracardiac abscess (P 0.035) and prior EE (P 0.042), as independent predictors of EEs, while valve surgery (P < 0.001) was associated with lower risk for EEs. We reported a high percentage of EEs among patients with left-side IE; vegetation size, intracardiac abscess, S. aureus and sepsis were independently associated with the occurrence of EEs. In addition to antibiotic treatment, early surgery led to further decrease in EEs incidence. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37402113; info:eu-repo/semantics/altIdentifier/eissn/1439-0973; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_A3211E03E2891; https://serval.unil.ch/notice/serval:BIB_A3211E03E289; https://serval.unil.ch/resource/serval:BIB_A3211E03E289.P001/REF.pdf |
| DOI: | 10.1007/s15010-023-02066-z |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_A3211E03E289 https://doi.org/10.1007/s15010-023-02066-z https://serval.unil.ch/resource/serval:BIB_A3211E03E289.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_A3211E03E2891 |
| Rights: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.B093E1E0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s15010-023-02066-z |
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