Academic Journal
VEGF dose controls the coupling of angiogenesis and osteogenesis in engineered bone
| العنوان: | VEGF dose controls the coupling of angiogenesis and osteogenesis in engineered bone |
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| المؤلفون: | Andrea Grosso, Alexander Lunger, Maximilian G. Burger, Priscilla S. Briquez, Francesca Mai, Jeffrey A. Hubbell, Dirk J. Schaefer, Andrea Banfi, Nunzia Di Maggio |
| المصدر: | npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-15 (2023) |
| بيانات النشر: | Nature Portfolio |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Vascular endothelial growth factor-A (VEGF) physiologically regulates both angiogenesis and osteogenesis, but its application in bone tissue engineering led to contradictory outcomes. A poorly understood aspect is how VEGF dose impacts the coordination between these two processes. Taking advantage of a unique and highly tunable platform, here we dissected the effects of VEGF dose over a 1,000-fold range in the context of tissue-engineered osteogenic grafts. We found that osteo-angiogenic coupling is exquisitely dependent on VEGF dose and that only a tightly defined dose range could stimulate both vascular invasion and osteogenic commitment of progenitors, with significant improvement in bone formation. Further, VEGF dose regulated Notch1 activation and the induction of a specific pro-osteogenic endothelial phenotype, independently of the promotion of vascular invasion. Therefore, in a therapeutic perspective, fine-tuning of VEGF dose in the signaling microenvironment is key to ensure physiological coupling of accelerated vascular invasion and improved bone formation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2057-3995 |
| Relation: | https://doi.org/10.1038/s41536-023-00288-1; https://doaj.org/toc/2057-3995; https://doaj.org/article/b2c3e5466f334d97b26723429f829ae9 |
| DOI: | 10.1038/s41536-023-00288-1 |
| الاتاحة: | https://doi.org/10.1038/s41536-023-00288-1 https://doaj.org/article/b2c3e5466f334d97b26723429f829ae9 |
| رقم الانضمام: | edsbas.B08182FD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20573995 |
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| DOI: | 10.1038/s41536-023-00288-1 |