Academic Journal
The deep genome project
| العنوان: | The deep genome project |
|---|---|
| المؤلفون: | Lloyd, K.C. Kent, Adams, David J., Baynam, Gareth, Beaudet, Arthur L., Bosch, Fatima, Boycott, Kym M., Braun, Robert E., Caulfield, Mark, Cohn, Ronald, Dickinson, Mary E., Dobbie, Michael S., Flenniken, Ann M., Flicek, Paul, Galande, Sanjeev, Gao, Xiang, Grobler, Anne, Heaney, Jason D., Herault, Yann, Hrabe de Angelis, Martin, Lupski, James R., Lyonnet, Stanislas, Mallon, Ann-Marie, Mammano, Fabio, MacRae, Calum A., McInnes, Roderick, McKerlie, Colin, Meehan, Terrence F., Murray, Stephen A., Nutter, Lauryl M.J., Obata, Yuichi, Parkinson, Helen, Pepper, Michael Sean, Sedlacek, Radislav, Seong, Je Kyung, Shiroishi, Toshihiko, Smedley, Damian, Tocchini-Valentini, Glauco, Valle, David, Leo Wang, Chi-Kuang, Wells, Sara, White, Jacqueline, Wurst, Wolfgang, Xu, Ying, Brown, Steve D.M. |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2020 |
| المجموعة: | University of Pretoria: UPSpace |
| مصطلحات موضوعية: | In vivo, Multi-organ systems, Laboratory, Medical advances |
| الوصف: | In vivo research is critical to the functional dissection of multi-organ systems and whole organism physiology, and the laboratory mouse remains a quintessential animal model for studying mammalian, especially human, pathobiology. Enabled by technological innovations in genome sequencing, mutagenesis and genome editing, phenotype analyses, and bioinformatics, in vivo analysis of gene function and dysfunction in the mouse has delivered new understanding of the mechanisms of disease and accelerated medical advances. However, many significant hurdles have limited the elucidation of mechanisms underlying both rare and complex, multifactorial diseases, leaving significant gaps in our scientific knowledge. Future progress in developing a functionally annotated genome map depends upon studies in model organisms, not least the mouse. Further, recent advances in genetic manipulation and in vivo, in vitro, and in silico phenotyping technologies in the mouse make annotation of the vast majority of functional elements within the mammalian genome feasible. The implementation of a Deep Genome Project—to deliver the functional biological annotation of all human orthologous genomic elements in mice—is an essential and executable strategy to transform our understanding of genetic and genomic variation in human health and disease that will catalyze delivery of the promised benefits of genomic medicine to children and adults around the world. ; http://genomebiology.com ; am2021 ; Immunology |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | http://hdl.handle.net/2263/78628; Llyod, K.C.K., Adams, D.J., Baynam, G. et al. 2020, 'The deep genome project', Genome Biology, vol. 21, art. 18, pp. 1-6.; 1465-6906 (print); 1474-760X (online) |
| DOI: | 10.1186/s13059-020-1931-9 |
| الاتاحة: | http://hdl.handle.net/2263/78628 https://doi.org/10.1186/s13059-020-1931-9 |
| Rights: | © The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. |
| رقم الانضمام: | edsbas.B06621BB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13059-020-1931-9 |
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