التفاصيل البيبلوغرافية
| العنوان: |
Domain Formation in Charged Polymer Vesicles |
| المؤلفون: |
Kaushik Chakraborty (1542139), Prabir Khatua (1738339), Wataru Shinoda (1733578), Sharon M. Loverde (657483) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Medicine, Cell Biology, Developmental Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, underlying mechanisms guiding, uncharged diblock copolymers, results add insight, phase behavior depends, next perform large, membrane thickness decreases, membrane overlap increases, bending modulus increase, polymersome membrane surface, area elastic modulus, charged polymer concentration, surface topology, salt concentration, elastic properties, using coarse, scale simulations, mixed charged, living cells, domain formation, divalent counterions |
| الوصف: |
Microphase separation can occur on a polymersome membrane surface. The phase behavior depends on the mixture of charged and uncharged diblock copolymers and the salt concentration in solution. Using coarse-grained molecular dynamics simulations, we evaluate the elastic properties of mixed charged and uncharged diblock copolymer membranes as a function of charged polymer concentration for the case of divalent counterions in solution. We find that both the area elastic modulus and bending modulus increase with increasing charged copolymer concentration. We find that the membrane thickness decreases and the membrane overlap increases with increasing charged copolymer concentration. We next perform large-scale simulations of a nearly 30 nm polymersome and characterize the growth of domains over a 0.5 μs simulation time. We characterize the size, shape, and surface topology of the domains as they grow. These results add insight into the underlying mechanisms guiding the growth of domains in both synthetic and living cells. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Domain_Formation_in_Charged_Polymer_Vesicles/16806633 |
| DOI: |
10.1021/acs.macromol.1c00762.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.macromol.1c00762.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.B0511406 |
| قاعدة البيانات: |
BASE |