التفاصيل البيبلوغرافية
| العنوان: |
Interaction between vitamin B6 metabolism, nitrogen metabolism and autoimmunity |
| المؤلفون: |
Colinas Martinez, Maite Felicitas, Fitzpatrick, Thérésa Bridget |
| المصدر: |
ISSN: 1559-2316 ; Plant signalling & behavior, vol. 11, no. 4 (2016) e1161876. |
| سنة النشر: |
2016 |
| المجموعة: |
Université de Genève: Archive ouverte UNIGE |
| مصطلحات موضوعية: |
info:eu-repo/classification/ddc/580 |
| الوصف: |
The essential micronutrient vitamin B6 is best known in its enzymatic cofactor form, pyridoxal 5'-phosphate (PLP). However, vitamin B6 comprises the amine pyridoxamine 5'-phosphate (PMP) and the alcohol pyridoxine 5'-phosphate (PNP) in addition to PLP, as well as their corresponding non-phosphorylated forms. The different B6 forms (called vitamers) are enzymatically interconverted in a ubiquitous salvage pathway. Recently, we have shown that balancing the ratio of the different B6 vitamers in particular PMP by the PMP/PNP oxidase PDX3 is essential for growth and development in Arabidopsis thaliana. Intriguingly, nitrate to ammonium conversion is impaired in pdx3 mutants, such that the mutants become ammonium-dependent, suggesting an interaction between vitamin B6 and nitrogen metabolism. In addition, we found a strong up-regulation of genes related to plant defense. Here, we further show that pdx3 mutants display a temperature-sensitive phenotype that is typical of autoimmune mutants and is possibly connected to the impaired nitrogen metabolism. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/27018849; https://archive-ouverte.unige.ch/unige:88857; unige:88857 |
| الاتاحة: |
https://archive-ouverte.unige.ch/unige:88857 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: |
edsbas.B0291927 |
| قاعدة البيانات: |
BASE |