Academic Journal
Cell Growth & Differentiation 419 Role of Increased Basal Expression of Heat Shock Protein 72
| العنوان: | Cell Growth & Differentiation 419 Role of Increased Basal Expression of Heat Shock Protein 72 |
|---|---|
| المؤلفون: | Mark W. Musch, Brian Kaplan, Eugene B. Chang |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://cgd.aacrjournals.org/cgi/reprint/12/8/419.pdf. |
| سنة النشر: | 2001 |
| المجموعة: | CiteSeerX |
| الوصف: | Although the expression of heat shock proteins (hsps) can be induced by a variety of stressful stimuli, certain neoplasms, including human intestinal T84, HT-29, and Caco2 adenocarcinoma cell lines, express constitutively high levels even under nonstress conditions. In this study, we examine the functional significance of increased hsp72 in spontaneously differentiating Caco2bbe (C2) cells. The expression of hsp72 in these cells was specifically inhibited by hsp72 antisense transfection. The loss of hsp72 expression did not affect growth rate, contact inhibition, morphological development, or functional differentiation. In contrast, these cells were significantly more sensitive to the injurious effects |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.316.1221; http://cgd.aacrjournals.org/cgi/reprint/12/8/419.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.316.1221 http://cgd.aacrjournals.org/cgi/reprint/12/8/419.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.AFECE6B3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |