Academic Journal
Keratin-hydrotalcites hybrid films for drug delivery applications
| العنوان: | Keratin-hydrotalcites hybrid films for drug delivery applications |
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| المؤلفون: | Posati T., Giuri D., Nocchetti M., Sagnella A., Gariboldi M., Ferroni C., Sotgiu G., Varchi G., Zamboni R., Aluigi A. |
| المساهمون: | Posati, T., Giuri, D., Nocchetti, M., Sagnella, A., Gariboldi, M., Ferroni, C., Sotgiu, G., Varchi, G., Zamboni, R., Aluigi, A. |
| سنة النشر: | 2018 |
| المجموعة: | IRIS Università degli Studi di Perugia |
| مصطلحات موضوعية: | Composite, Cytocompatibility, Drug release, Hydrotalcyte, Keratin |
| الوصف: | In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000441855800020; volume:105; firstpage:177; lastpage:185; numberofpages:9; journal:EUROPEAN POLYMER JOURNAL; http://hdl.handle.net/11391/1451256; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85048597047; https:/doi.org/10.1016/j.eurpolymj.2018.05.030 |
| DOI: | 10.1016/j.eurpolymj.2018.05.030 |
| الاتاحة: | http://hdl.handle.net/11391/1451256 https://doi.org/10.1016/j.eurpolymj.2018.05.030 |
| رقم الانضمام: | edsbas.AFE76D8C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.eurpolymj.2018.05.030 |
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