Academic Journal
Local immunization impacts the response of dairy cows to Escherichia coli mastitis
| العنوان: | Local immunization impacts the response of dairy cows to Escherichia coli mastitis |
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| المؤلفون: | Herry, Vincent, Gitton, Christophe, Tabouret, Guillaume, Ferter, Maryline, Forge, Laurine, Tasca, Christian, Gilbert, Florence B., Guitton, Edouard, Barc, Céline, Staub, Christophe, Smith, David G.E., Germon, Pierre, Foucras, Gilles, Rainard, Pascal |
| المساهمون: | Interactions hôtes-agents pathogènes Toulouse (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Plateforme d'Infectiologie Expérimentale (PFIE), Institut National de la Recherche Agronomique (INRA), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University Edinburgh (HWU), "Investissements d’avenir" grant managed by Agence Nationale de la Recherche under the reference ANR-11-EQPX-0003, ANR-11-EQPX-0003,ANINFIMIP,Equipements plateforme animalerie infectieuse de haute-sécurité de Midi Pyrénées(2011), European Project: 291815,EC:FP7:KBBE,FP7-ERANET-2011-RTD,ANIHWA(2012) |
| المصدر: | ISSN: 2045-2322. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2017 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | dairy cattle, dairy cows, mammary gland, bovine mastitis, immunologic reactions, mammite bovine, réponse immunitaire, bovin laitier, vache laitière, escherichia coli, glande mammaire, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, [SDV.IMM]Life Sciences [q-bio]/Immunology |
| الوصف: | Remerciements :Jean-Luc Touzé and Eric Venturi for help in performing ultrasonography ; International audience ; Current vaccines to Escherichia coli mastitis have shown some albeit limited efficacy. Their mode of action has not been documented, and immune responses protecting the mammary gland against E. coli are not completely understood. To improve our knowledge of mammary gland immune protection, cows immunized either intramuscularly or intramammarily with the E. coli P4 were submitted to a homologous mastitis challenge. A third group of mock-immunized cows serve as challenge controls. Local immunization modified favorably the course of infection, by improving bacterial clearance while limiting inflammation. Systemic clinical signs and reduction in milk secretion were also contained. This occurred with a modification of the cytokine profile, such as an increase in IFN-γ and a reduction in TNF-α concentrations in milk. Concentrations of IL-17A and IL-22 increased in milk at the onset of the inflammatory response and remained high up to the elimination of bacteria, but concentrations did not differ between groups. Accelerated bacteriological cure was not linked to an increase in the initial efficiency of phagocytosis in milk. Results support the idea that antibodies did not play a major role in the improvement, and that cell-mediated immunity is the key to understanding E. coli vaccine-induced protection of the mammary gland. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/grantAgreement/EC/FP7/291815/EU/Animal Health and Welfare/ANIHWA; PRODINRA: 396635; WOS: 000403140000112 |
| DOI: | 10.1038/s41598-017-03724-7 |
| الاتاحة: | https://hal.science/hal-01608363 https://hal.science/hal-01608363v1/document https://hal.science/hal-01608363v1/file/2017_Herry_ScientificReports_1.pdf https://doi.org/10.1038/s41598-017-03724-7 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.AFCB4EE9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-017-03724-7 |
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