Academic Journal
Dosimetric effect of set-up error in accelerator-based boron neutron capture therapy for head and neck cancer
| العنوان: | Dosimetric effect of set-up error in accelerator-based boron neutron capture therapy for head and neck cancer |
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| المؤلفون: | Komori, Shinya, Hirose, Katsumi, Sato, Mariko, Takeuchi, Akihiko, Kato, Ryohei, Motoyanagi, Tomoaki, Harada, Takaomi, Yamazaki, Yuhei, Harada, Mayumi, Narita, Yuki, Kato, Takahiro, Takai, Yoshihiro |
| المصدر: | Journal of Radiation Research ; volume 63, issue 4, page 684-695 ; ISSN 0449-3060 1349-9157 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| الوصف: | The dosimetric effect of set-up error in boron neutron capture therapy (BNCT) for head and neck cancer remains unclear. In this study, we analyzed the tendency of dose error by treatment location when simulating the set-up error of patients. We also determined the tolerance level of the set-up error in BNCT for head and neck cancer. As a method, the distal direction was shifted with an interval of 2.5 mm, from 0.0 mm to +20.0 mm and compared with the dose at the reference position. Similarly, the horizontal direction and vertical direction were shifted, with an interval of 5.0 mm, from −20.0 mm to +20.0 mm. In addition, cases with 3.0 mm and 5.0 mm simultaneous shifts in all directions were analyzed as the worst-case scenario. The dose metrics of the minimum dose of the tumor and the maximum dose of the mucosa were evaluated. From unidirectional set-up error analysis, in most cases, the set-up errors with dose errors within ±5% were Δdistal < +2.5 mm, Δhorizontal < ±5.0 mm and Δvertical < ±5.0 mm. In the simulation of 3.0 mm shifts in all directions, the errors in the minimum tumor dose and maximum mucosal dose were −3.6% ±1.4% (range, −5.4% to −0.6%) and 2% ±1.4% (range, 0.4% to 4.5%), respectively. From these results, if the set-up error was within ±3.0 mm in each direction, the dose errors of the tumor and mucosa could be suppressed within approximately ±5%, which is suggested as a tolerance level. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/jrr/rrac017 |
| الاتاحة: | https://doi.org/10.1093/jrr/rrac017 https://academic.oup.com/jrr/article-pdf/63/4/684/45023492/rrac017.pdf |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.AFAE02C9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jrr/rrac017 |
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