التفاصيل البيبلوغرافية
| العنوان: |
Sarcoidosis, Mycobacterium paratuberculosis and Noncaseating Granulomas: Who Moved My Cheese |
| المؤلفون: |
Coad Thomas Dow, Nancy W. Lin, Edward D. Chan |
| المصدر: |
Microorganisms; Volume 11; Issue 4; Pages: 829 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
sarcoidosis, Mycobacterium avium subsp. paratuberculosis, MAP, non-caseating granuloma, caseating granuloma, Blau syndrome, early onset sarcoidosis, Crohn’s disease, cell wall deficient (CWD), L-form, Mycobacterium tuberculosis, acid-fast bacilli, SLC11a1 ( NRAMP1 ), NOD2 ( CARD15 ) |
| جغرافية الموضوع: |
agris |
| الوصف: |
Clinical and histological similarities between sarcoidosis and tuberculosis have driven repeated investigations looking for a mycobacterial cause of sarcoidosis. Over 50 years ago, “anonymous mycobacteria” were suggested to have a role in the etiology of sarcoidosis. Both tuberculosis and sarcoidosis have a predilection for lung involvement, though each can be found in any area of the body. A key histopathologic feature of both sarcoidosis and tuberculosis is the granuloma—while the tuberculous caseating granuloma has an area of caseous necrosis with a cheesy consistency; the non-caseating granuloma of sarcoidosis does not have this feature. This article reviews and reiterates the complicity of the infectious agent, Mycobacterium avium subsp. paratuberculosis (MAP) as a cause of sarcoidosis. MAP is involved in a parallel story as the putative cause of Crohn’s disease, another disease featuring noncaseating granulomas. MAP is a zoonotic agent infecting ruminant animals and is found in dairy products and in environmental contamination of water and air. Despite increasing evidence tying MAP to several human diseases, there is a continued resistance to embracing its pleiotropic roles. “Who Moved My Cheese” is a simple yet powerful book that explores the ways in which individuals react to change. Extending the metaphor, the “non-cheesy” granuloma of sarcoidosis actually contains the difficult-to-detect “cheese”, MAP; MAP did not move, it was there all along. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Medical Microbiology; https://dx.doi.org/10.3390/microorganisms11040829 |
| DOI: |
10.3390/microorganisms11040829 |
| الاتاحة: |
https://doi.org/10.3390/microorganisms11040829 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.AF5B605B |
| قاعدة البيانات: |
BASE |