Academic Journal
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase ; ENEngelskEnglishMitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
| العنوان: | Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase ; ENEngelskEnglishMitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase |
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| المؤلفون: | Ramos Alonso, Lucia, Holland, Petter, Le Gras, Stéphanie, Zhao, Xu, Jost, Bernard, Bjørås, Magnar, Barral, Yves, Enserink, Jorrit, Chymkowitch, Pierre |
| المصدر: | 0027-8424. |
| بيانات النشر: | The National Academy of Sciences |
| سنة النشر: | 2023 |
| المجموعة: | Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| الوصف: | Mitotic entry correlates with the condensation of the chromosomes, changes in histone modifications, exclusion of transcription factors from DNA, and the broad downregulation of transcription. However, whether mitotic condensation influences transcription in the subsequent interphase is unknown. Here, we show that preventing one chromosome to condense during mitosis causes it to fail resetting of transcription. Rather, in the following interphase, the affected chromosome contains unusually high levels of the transcription machinery, resulting in abnormally high expression levels of genes in cis, including various transcription factors. This subsequently causes the activation of inducible transcriptional programs in trans, such as the GAL genes, even in the absence of the relevant stimuli. Thus, mitotic chromosome condensation exerts stringent control on interphase gene expression to ensure the maintenance of basic cellular functions and cell identity across cell divisions. Together, our study identifies the maintenance of transcriptional homeostasis during interphase as an unexpected function of mitosis and mitotic chromosome condensation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | HSØ/2017064; HSØ/2018012; HSØ/2019096; KF/182524; NFR/287911; KF/208012; NFR/262652; NFR/261936; NFR/294916; NFR/314811; NFR/301268; Ramos Alonso, Lucia Holland, Petter Le Gras, Stéphanie Zhao, Xu Jost, Bernard Bjørås, Magnar Barral, Yves Enserink, Jorrit Chymkowitch, Pierre . Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase. Proceedings of the National Academy of Sciences of the United States of America. 2023, 120(4), 1-8; http://hdl.handle.net/10852/105954; 2131067; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings of the National Academy of Sciences of the United States of America&rft.volume=120&rft.spage=1&rft.date=2023; Proceedings of the National Academy of Sciences of the United States of America; 120; https://doi.org/10.1073/pnas.2210593120 |
| DOI: | 10.1073/pnas.2210593120 |
| الاتاحة: | http://hdl.handle.net/10852/105954 https://doi.org/10.1073/pnas.2210593120 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.AF42C64A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1073/pnas.2210593120 |
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