Academic Journal
3D high-precision melt electro written polycaprolactone modified with yeast derived peptides for wound healing
| العنوان: | 3D high-precision melt electro written polycaprolactone modified with yeast derived peptides for wound healing |
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| المؤلفون: | Mirzaei, Mahta, Dodi, Gianina, Gardikiotis, Ioannis, Pasca, Sorin-Aurelian, Mirdamadi, Saeed, Subra, Gilles, Echalier, Cécile, Puel, Chloé, Morent, Rino, Ghobeira, Rouba, Soleymanzadeh, Nazila, Moser, Muriel, Goriely, Stanislas, Shavandi, Amin |
| المساهمون: | Université libre de Bruxelles (ULB), Ecole Polytechnique de Bruxelles, GHENT UNIVERSITY GLOBAL CAMPUS INCHEON KOR, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Universiteit Gent = Ghent University = Université de Gand (UGENT), University of Medicine and Pharmacy "Grigore T.Popa" Iasi (UMF lasi), Universitatea de Ştiinţe Agricole şi Medicină Veterinară "Ion Ionescu de la Brad" - University of life sciences Iasi, Romania, Iranian Research Organization for Science and Technology (IROST), Institut des Biomolécules Max Mousseron Pôle Chimie Balard (IBMM), Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM) |
| المصدر: | ISSN: 2772-9516. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | Melt electro writing, Peptide-functionalized polymer, Poly (ε-caprolactone), Wound healing, Yeast derived peptide, MESH: Rats, MESH: Animals, MESH: Tissue Scaffolds, MESH: Saccharomyces cerevisiae, MESH: Wound Healing, MESH: Peptides, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, [CHIM.POLY]Chemical Sciences/Polymers |
| الوصف: | International audience ; In this study melt electro written (MEW) scaffolds of poly(ε-caprolactone) PCL are decorated with anti-inflammatory yeast-derived peptide for skin wound healing. Initially, 13 different yeast-derived peptides were screened and analyzed using both in vitro and in vivo assays. The MEW scaffolds are functionalized with the selected peptide VLSTSFPPW (VW-9) with the highest activity in reducing pro-inflammatory cytokines and stimulating fibroblast proliferation, migration, and collagen production. The peptide was conjugated to the MEW scaffolds using carbodiimide (CDI) and thiol chemistry, with and without plasma treatment, as well as by directly mixing the peptide with the polymer before printing. The MEW scaffolds modified using CDI and thiol chemistry with plasma treatment showed improved fibroblast and macrophage penetration and adhesion, as well as increased cell proliferation and superior anti-inflammatory properties, compared to the other groups. When applied to full-thickness excisional wounds in rats, the peptide-modified MEW scaffold significantly enhanced the healing process compared to controls (p < 0.05). This study provides proof of concept for using yeast-derived peptides to functionalize biomaterials for skin wound healing. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36965401; PUBMED: 36965401 |
| DOI: | 10.1016/j.bioadv.2023.213361 |
| الاتاحة: | https://hal.science/hal-04601869 https://hal.science/hal-04601869v1/document https://hal.science/hal-04601869v1/file/Mirzaei%20version%20HAL.pdf https://doi.org/10.1016/j.bioadv.2023.213361 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.AF3FF80B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.bioadv.2023.213361 |
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