التفاصيل البيبلوغرافية
| العنوان: |
Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody |
| المؤلفون: |
McLellan, Jason S., Chen, Man, Leung, Sherman, Graepel, Kevin W., Du, Xiulian, Yang, Yongping, Zhou, Tongqing, Baxa, Ulrich, Yasuda, Etsuko, Beaumont, Tim, Kumar, Azad, Modjarrad, Kayvon, Zheng, Zizheng, Zhao, Min, Xia, Ningshao, Kwong, Peter D., Gr, 郑子峥, 夏宁邵 |
| المصدر: |
http://dx.doi.org/10.1126/science.1234914. |
| بيانات النشر: |
AMER ASSOC ADVANCEMENT SCIENCE |
| سنة النشر: |
2013 |
| المجموعة: |
Xiamen University Institutional Repository |
| مصطلحات موضوعية: |
RESPIRATORY SYNCYTIAL VIRUS, MONOCLONAL-ANTIBODY, F-GLYCOPROTEIN, PROTEIN, INFECTION, EPITOPES, CONFORMATION, MOTAVIZUMAB, CHILDREN, SEQUENCE |
| الوصف: |
Intramural Research Program (National Institute of Allergy and Infectious Diseases); National Natural Science Foundation of China [81161120419]; U.S. Department of Energy, Basic Energy Sciences, Office of Science [W-31-109-Eng-38] ; The prefusion state of respiratory syncytiat virus (RSV) fusion (F) glycoprotein is the target of most RSV-neutralizing activity in human sera, but its metastability has hindered characterization. To overcome this obstacle, we identified prefusion-specific antibodies that were substantially more potent than the prophylactic antibody palivizumab. The cocrystal structure for one of these antibodies, D25, in complex with the F glycoprotein revealed D25 to lock F in its prefusion state by binding to a quaternary epitope at the trimer apex. Electron microscopy showed that two other antibodies, AM22 and 5C4, also bound to the newly identified site of vulnerability, which we named antigenic site empty set. These studies should enable design of improved vaccine antigens and define new targets for passive prevention of RSV-induced disease |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
SCIENCE, 2013,340(6136):1113-1117; WOS:000319664500049; http://dspace.xmu.edu.cn/handle/2288/87567 |
| الاتاحة: |
http://dspace.xmu.edu.cn/handle/2288/87567 |
| رقم الانضمام: |
edsbas.AF1A46EC |
| قاعدة البيانات: |
BASE |