Conference
Early subclinical cardiovascular changes after radiotherapy detected by echocardiography in women with breast cancer: contribution of the MEDIRAD EARLY-HEART cohort
| العنوان: | Early subclinical cardiovascular changes after radiotherapy detected by echocardiography in women with breast cancer: contribution of the MEDIRAD EARLY-HEART cohort |
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| المؤلفون: | Locquet, Médéa, Jacob, Sophie, Crijns, A.P.G., Langendijk, J.A., Spoor, Daan, Eraso, Arantxa, Guedea, Ferran, Fiuza, Manuela, Constantino Rosa Santos, Susana, Combs, Stephanie, Borm, Kai, Frija, Guy, Cardis, Elisabeth |
| المساهمون: | Laboratoire d épidémiologie des rayonnements ionisants (IRSN/PSE-SANTE/SESANE/LEPID), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), University Medical Center Groningen Groningen (UMCG), Catalan Institute of Oncology Girona (ICO-Girona), Catalan Institute of Oncology = Instituto Catalán de Oncología (ICO), Cardiovascular Centre of the University of Lisbon (CCUL), Universidade de Lisboa = University of Lisbon = Université de Lisbonne (ULISBOA), Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM), Université Paris Cité (UPCité), Universitat Pompeu Fabra Barcelona (UPF) |
| المصدر: | ImmunoRad Conference: The International Conference and Immunotherapy Radiotherapy Combination ; https://hal.science/hal-04495199 ; ImmunoRad Conference: The International Conference and Immunotherapy Radiotherapy Combination, Sep 2021, Paris, France |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| جغرافية الموضوع: | Paris, France |
| الوصف: | International audience ; Background: Breast cancer (BC) represents a major public health burden worldwide. Significant advances in treatments have been made in recent decades. Among them, radiotherapy (RT) allows reducing local recurrence and deaths resulting from BC. However, RT for BC can lead to cardiotoxicity, resulting in an increased risk of long-term major cardiovascular adverse events (MACE). Consequently, to detect early subclinical cardiac alterations is of primary importance.Objective: One of the aims of the MEDIRAD EARLY-HEART study is to determine the short-term impact of BC RT on subclinical cardiac function by means of echocardiography and to explore the dose-response relationship. Methods: Launched in 2017, the ongoing EARLY-HEART study is a prospective multicenter cohort study including women with BC aged 40 to 75 years and treated by RT in the Netherlands, Germany, France, Portugal and Spain. All women were chemotherapy naive. Echocardiographic exams after the RT+6-month follow-up (FU) will be available in September 2021 to determine if significant subclinical cardiac function alterations occurred. A RT+24-month FU is currently ongoing to determine if eventual previous alterations persist. Myocardial deformation analysis was provided by the 2D-speckle-tracking echocardiography. The global longitudinal strain (GLS), its worsening > 10% and the global longitudinal strain rate (GLSR) will be considered to evaluate subclinical cardiac dysfunction. Results: The EARLY-HEART cohort included 258 women with BC, with a mean age of 58.2±8.1 years, 63.5% with left-sided BC. Presence of pre-existing cardiovascular (CV) risk factors were recorded to allow adjustments in further analyses: obesity was present in 21.0% of the sample (mean body mass index of 26.3±4.6 kg/m²), hypertension in 48.2%, diabetes in 5.4% and 47.8% were current or former smoker. RT total dose varied from 40.05 Gray (Gy) to 50.40 Gy, and 46.1% received a boost (mean boost dose of 11.9±1.9 Gy). Among the 258 patients, 63.9% received ... |
| نوع الوثيقة: | conference object still image |
| اللغة: | English |
| الاتاحة: | https://hal.science/hal-04495199 https://hal.science/hal-04495199v1/document https://hal.science/hal-04495199v1/file/LocquetM%20et%20al.%20ImmunoRad2021_Poster.pdf |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.AF1472B0 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |