التفاصيل البيبلوغرافية
| العنوان: |
COVID-19 Inflammatory Markers and Vitamin D Relationship in Pediatric Patients |
| المؤلفون: |
Iulia Cristina Bagiu, Ileana Luminita Scurtu, Delia Ioana Horhat, Ion Cristian Mot, Razvan Mihai Horhat, Radu Vasile Bagiu, Ionut Dragos Capraru, Mircea Mihai Diaconu, Ovidiu Adam, Bogdan Ciornei, Dan Dumitru Vulcanescu, Iulius Juganaru, Andrei-Cristian Bondar, Florin George Horhat |
| المصدر: |
Life; Volume 13; Issue 1; Pages: 91 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
COVID-19, SARS-CoV-2, creatine kinase, lactate dehydrogenase, C reactive protein, vitamin D, children |
| جغرافية الموضوع: |
agris |
| الوصف: |
Background: Biomarkers play an important role in COVID-19, and more research in this regard is needed, especially in the case of children. This study aimed to look for a link between the C reactive protein (CRP), lactate dehydrogenase (LDH), creatine kinase (CK), vitamin D and COVID-19 in pediatric patients. Methods: This is a retrospective cohort study, performed on children diagnosed positively with COVID-19 at a children’s hospital in western Romania. Available CRP, LDH, CK vitamin D and clinical severity were recorded. For each biomarker, groups were formed by patients’ age. Mean/median group differences were assessed using Student’s t test or Mann–Whitney and Kruskal–Wallis with Dunn’s post hoc tests. Association was assessed using the chi2 test, while correlation was assessed using Spearman’s rank correlation. Results: 181 positive children were studied between 1 August 2021 and 1 February 2022. Average age was 8.76 years (SD = 3.93). There were 94 (51.93%) males and 87 (48.07%) females. The cases were: 62 asymptomatic (34.25%), 107 mild (59.12%), 9 moderate (4.97%), 3 severe (1.66%). Regarding CRP, a significant difference between older and younger patients was observed (p = 0.0034). Clinical severity was associated with CRP (p = 0.0281), LDH (p = 0.0410) and vitamin D (p = 0.0444). Regarding CK, no differences or associations proved significant. Correlation testing was conducted for CRP, LDH, vitamin D and clinical signs. With the exception of LDH-CRP and LDH-vitamin D, all relationships proved statistically significant. Conclusions: CRP, LDH and vitamin D levels are important biomarkers for COVID-19-positive pediatric patients, while CK was mostly within normal ranges. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Epidemiology; https://dx.doi.org/10.3390/life13010091 |
| DOI: |
10.3390/life13010091 |
| الاتاحة: |
https://doi.org/10.3390/life13010091 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.AEE2B6F6 |
| قاعدة البيانات: |
BASE |