Academic Journal
Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice.
| العنوان: | Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice. |
|---|---|
| المؤلفون: | Gomez-Samblas, M, Bernal, D, Bolado-Ortiz, A, Vilchez, S, Bolás-Fernández, F, Espino, A M, Trelis, M, Osuna, A |
| سنة النشر: | 2018 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Animals, Antibodies, Monoclonal, Injections, Intraperitoneal, Interleukin-23, Interleukins, Intestines, Male, Mice, Inbred ICR, Nematode Infections, Parasite Load |
| الوصف: | Previous studies have established that an increased Th-9 response creates a hostile environment for nematode parasites. Given that IL-23, a cytokine required for maintenance of the IL-17-secreting phenotype, has inhibitory effects on IL-9 production, we hypothesized that reducing circulating IL-23 by treatment with anti-IL-23 antibodies would reduce the establishment and development of parasitic intestinal nematodes. In this study, we show that animals treated with anti-IL-23 monoclonal antibodies showed a drastic reduction in the number of mouse pinworms (Aspiculuris tetraptera) recovered from the intestine (p |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | http://hdl.handle.net/10668/12484; PMC5958071; https://www.nature.com/articles/s41598-018-26194-x.pdf; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958071/pdf |
| DOI: | 10.1038/s41598-018-26194-x |
| الاتاحة: | http://hdl.handle.net/10668/12484 https://doi.org/10.1038/s41598-018-26194-x https://www.nature.com/articles/s41598-018-26194-x.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958071/pdf |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; open access |
| رقم الانضمام: | edsbas.AEDBF074 |
| قاعدة البيانات: | BASE |
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