Academic Journal
أعرض في EDS

Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice.

التفاصيل البيبلوغرافية
العنوان: Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice.
المؤلفون: Gomez-Samblas, M, Bernal, D, Bolado-Ortiz, A, Vilchez, S, Bolás-Fernández, F, Espino, A M, Trelis, M, Osuna, A
سنة النشر: 2018
المجموعة: Sistema Sanitario Público de Andalucía (SSPA): Repositorio
مصطلحات موضوعية: Animals, Antibodies, Monoclonal, Injections, Intraperitoneal, Interleukin-23, Interleukins, Intestines, Male, Mice, Inbred ICR, Nematode Infections, Parasite Load
الوصف: Previous studies have established that an increased Th-9 response creates a hostile environment for nematode parasites. Given that IL-23, a cytokine required for maintenance of the IL-17-secreting phenotype, has inhibitory effects on IL-9 production, we hypothesized that reducing circulating IL-23 by treatment with anti-IL-23 antibodies would reduce the establishment and development of parasitic intestinal nematodes. In this study, we show that animals treated with anti-IL-23 monoclonal antibodies showed a drastic reduction in the number of mouse pinworms (Aspiculuris tetraptera) recovered from the intestine (p
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 2045-2322
Relation: http://hdl.handle.net/10668/12484; PMC5958071; https://www.nature.com/articles/s41598-018-26194-x.pdf; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958071/pdf
DOI: 10.1038/s41598-018-26194-x
الاتاحة: http://hdl.handle.net/10668/12484
https://doi.org/10.1038/s41598-018-26194-x
https://www.nature.com/articles/s41598-018-26194-x.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958071/pdf
Rights: Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; open access
رقم الانضمام: edsbas.AEDBF074
قاعدة البيانات: BASE
الوصف
تدمد:20452322
DOI:10.1038/s41598-018-26194-x