Academic Journal
Adherence to response-guided pegylated interferon and ribavirin for people who inject drugs with hepatitis C virus genotype 2/3 infection: The ACTIVATE study
| العنوان: | Adherence to response-guided pegylated interferon and ribavirin for people who inject drugs with hepatitis C virus genotype 2/3 infection: The ACTIVATE study |
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| المؤلفون: | Cunningham, EB, Hajarizadeh, B, Dalgard, O, Amin, J, Hellard, M, Foster, GR, Bruggmann, P, Conway, B, Backmund, M, Robaeys, G, Swan, T, Marks, PS, Quiene, S, Applegate, TL, Weltman, M, Shaw, D, Dunlop, A, Bruneau, J, Midgard, H, Bourgeois, S, Thurnheer, MC, Dore, GJ, Grebely, J, Shaw, I, Siriragavan, S, Horschik, T, Sharma, S, Eevers, A, Andreassen, J, Melkeraaen, I, Widder, N, Lesneuck, K, Kotsoros, B, Hazelwood, S, Holland, R, Axten, D, Von Bibra, S, Powis, J, Mason, K, Ryder, S, Jack, K, Scheidegger, C, Huber, C, Ferguson, C, Staehelin, C, Lacalamita, M, Fragomeli, V, Sevehon, A |
| المصدر: | urn:ISSN:1471-2334 ; BMC Infectious Diseases, 17, 1, 420 |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2017 |
| المجموعة: | UNSW Sydney (The University of New South Wales): UNSWorks |
| مصطلحات موضوعية: | 32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, Drug Abuse (NIDA only), Chronic Liver Disease and Cirrhosis, Hepatitis, Infectious Diseases, Hepatitis - C, Digestive Diseases, Emerging Infectious Diseases, Liver Disease, Substance Misuse, Clinical Trials and Supportive Activities, Clinical Research, 6.1 Pharmaceuticals, Infection, 3 Good Health and Well Being, Adult, Antiviral Agents, Drug Therapy, Combination, Female, Genotype, Hepacivirus, Hepatitis C, Humans, Interferon alpha-2, Interferon-alpha, Male, Middle Aged, Opiate Substitution Treatment |
| الوصف: | Background: The aims of this analysis were to investigate treatment completion and adherence among people with ongoing injecting drug use or receiving opioid substitution therapy (OST) in a study of response-guided therapy for chronic HCV genotypes 2/3 infection. Methods: ACTIVATE was a multicenter clinical trial recruited between 2012 and 2014. Participants with genotypes 2/3 were treated with directly observed peg-interferon alfa-2b (PEG-IFN) and self-administered ribavirin for 12 (undetectable HCV RNA at week 4) or 24 weeks (detectable HCV RNA at week 4). Outcomes included treatment completion, PEG-IFN adherence, ribavirin adherence, and sustained virological response (SVR, undetectable HCV RNA >12 weeks post-treatment). Results: Among 93 people treated, 59% had recently injected drugs (past month), 77% were receiving OST and 56% injected drugs during therapy. Overall, 76% completed treatment. Mean on-treatment adherence to PEG-IFN and ribavirin were 98.2% and 94.6%. Overall, 6% of participants missed >1 dose of PEG-IFN and 31% took <95% of their prescribed ribavirin., Higher treatment completion was observed among those receiving 12 vs. 24 weeks of treatment (97% vs. 46%, P < 0.001) while the proportion of participants with 95% on-treatment ribavirin adherence was similar between groups (67% vs. 72%, P = 0.664). Receiving 12 weeks of therapy was independently associated with treatment completion. No factors were associated with 95% RBV adherence. Neither recent injecting drug use at baseline nor during therapy was associated with treatment completion or adherence to ribavirin. In adjusted analysis, treatment completion was associated with SVR (aOR 23.9, 95% CI 2.9-193.8). Conclusions: This study demonstrated a high adherence to directly observed PEG-IFN and self-administered ribavirin among people with ongoing injecting drug use or receiving OST. These data also suggest that shortening therapy from 24 to 12 weeks can lead to improved treatment completion. Treatment completion was associated with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | http://hdl.handle.net/1959.4/unsworks_53437 |
| DOI: | 10.1186/s12879-017-2517-3 |
| الاتاحة: | http://hdl.handle.net/1959.4/unsworks_53437 https://doi.org/10.1186/s12879-017-2517-3 |
| Rights: | open access ; https://purl.org/coar/access_right/c_abf2 ; CC BY ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.AE9D213E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12879-017-2517-3 |
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