Academic Journal
Genome-wide expression reveals multiple systemic effects associated with detection of anticoagulant poisons in bobcats (Lynx rufus).
| العنوان: | Genome-wide expression reveals multiple systemic effects associated with detection of anticoagulant poisons in bobcats (Lynx rufus). |
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| المؤلفون: | Fraser, Devaughn, Mouton, Alice, Serieys, Laurel E. K., Cole, Steve, Carver, Scott, Vandewoude, Sue, Lappin, Michael, Riley, Seth P. D., Wayne, Robert |
| المصدر: | Molecular Ecology, 27 (5), 1170-1187 (2018) |
| بيانات النشر: | Wiley |
| سنة النشر: | 2018 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Adaptive Immunity/drug effects, Animals, Anticoagulants/toxicity, California, Disease Susceptibility/chemically induced, Endoplasmic Reticulum Stress, Environmental Exposure, Environmental Pollutants/toxicity, Food Chain, Gene Expression Profiling, Genome/drug effects, Immunity, Innate/drug effects, Lynx/genetics/metabolism, Principal Component Analysis, Rodenticides/toxicity, Xenobiotics/metabolism/toxicity, anticoagulant rodenticides, bobcats, gene expression, secondary poisoning, Life sciences, Zoology, Sciences du vivant, Zoologie |
| الوصف: | peer reviewed ; Anticoagulant rodenticides (ARs) are indiscriminate toxicants that threaten nontarget predatory and scavenger species through secondary poisoning. Accumulating evidence suggests that AR exposure may have disruptive sublethal consequences on individuals that can affect fitness. We evaluated AR-related effects on genome-wide expression patterns in a population of bobcats in southern California. We identify differential expression of genes involved in xenobiotic metabolism, endoplasmic reticulum stress response, epithelial integrity and both adaptive and innate immune function. Further, we find that differential expression of immune-related genes may be attributable to AR-related effects on leucocyte differentiation. Collectively, our results provide an unprecedented understanding of the sublethal effects of AR exposure on a wild carnivore. These findings highlight potential detrimental effects of ARs on a wide variety of species worldwide that may consume poisoned rodents and indicate the need to investigate gene expression effects of other toxicants added to natural environments by humans. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0962-1083 1365-294X |
| Relation: | urn:issn:0962-1083; urn:issn:1365-294X; https://orbi.uliege.be/handle/2268/255833; info:hdl:2268/255833; https://orbi.uliege.be/bitstream/2268/255833/1/MolEcol_postprint.pdf; info:pmid:29427407 |
| DOI: | 10.1111/mec.14531 |
| الاتاحة: | https://orbi.uliege.be/handle/2268/255833 https://orbi.uliege.be/bitstream/2268/255833/1/MolEcol_postprint.pdf https://doi.org/10.1111/mec.14531 |
| Rights: | open access ; http://purl.org/coar/access_right/c_abf2 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AE4C5B0F |
| قاعدة البيانات: | BASE |
| تدمد: | 09621083 1365294X |
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| DOI: | 10.1111/mec.14531 |