Academic Journal
Morning salivary cortisol in young children: reference values and the effects of age, sex, and acute bronchiolitis
| العنوان: | Morning salivary cortisol in young children: reference values and the effects of age, sex, and acute bronchiolitis |
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| المؤلفون: | Rolfsjord, Leif Bjarte, Bakkeheim, Egil, Berents, Teresa Løvold, Alm, Johan, Skjerven, Håvard Ove, Carlsen, Kai-Håkon, Mowinckel, Petter, Sjöbeck, Ann-Christine, Carlsen, Karin C. Lødrup |
| المصدر: | 193-198 ; 184 ; Journal of Pediatrics |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | adrenocortical function, allergic disease, allergic rhinitis, asthma, health-related quality of life, infants, morning salivary cortisol, stress, toddlers |
| جغرافية الموضوع: | Norway |
| الوصف: | OBJECTIVE: To identify morning salivary cortisol reference values in infancy and at 2 years of age and to investigate the influence of age, sex and acute bronchiolitis. STUDY DESIGN: In this South-East Norwegian cohort study, 308 children hospitalized with moderate to severe acute bronchiolitis in infancy in 2010-2011 were compared with 223 healthy controls included in 2012 by measuring morning salivary cortisol levels at inclusion and at 2 years of age. Samples were collected shortly after awakening after 6 am. The influences of age, sex, and acute bronchiolitis were assessed by regression analysis. RESULTS: In infancy, cortisol values were higher in acute bronchiolitis, with an age- and sex-adjusted weighted mean group difference of 13.9 nmol/L (95% CI 8.1-19.7; P < .0001). The median level in reference group was 23.7 nmol/L (95% CI 9.7-119.6). At 2 years of age, sex but not inclusion groups differed, with significantly higher values in girls. The weighted mean of all boys' cortisol levels was 32.4 nmol/L, (95% CI 30.5-34.3), and all girls' levels were 36.9 nmol/L (95% CI 34.7-39.2; P < .003). CONCLUSIONS: Salivary cortisol levels were higher at 2 years of age than in infancy in the reference group, were higher in girls than in boys at 2 years of age, and were higher in infants at the time of acute bronchiolitis than in healthy infants. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00817466. ; publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Regionale forskningsfond Innlandet: 150189; http://hdl.handle.net/11250/2567379; https://doi.org/10.1016/j.jpeds.2017.01.064; cristin:1502993 |
| DOI: | 10.1016/j.jpeds.2017.01.064 |
| الاتاحة: | http://hdl.handle.net/11250/2567379 https://doi.org/10.1016/j.jpeds.2017.01.064 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal ; http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no ; © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). http://dx.doi.org/10.1016/j.jpeds.2017.01.064 THE JOURNAL OF PEDIATRICS • www.jpeds.com ORIGINAL ARTICLES 193 |
| رقم الانضمام: | edsbas.AE0B00C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jpeds.2017.01.064 |
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