Academic Journal
Interpreting Iron Homeostasis in Congenital and Acquired Disorders
| العنوان: | Interpreting Iron Homeostasis in Congenital and Acquired Disorders |
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| المؤلفون: | Scaramellini N., Fischer D., Agarvas A. R., Motta I., Muckenthaler M. U., Mertens C. |
| المساهمون: | N. Scaramellini, D. Fischer, A.R. Agarva, I. Motta, M.U. Muckenthaler, C. Mertens |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | anemia, hematology, hemochromatosi, iron, iron deficiency, iron metabolism, iron overload, rare disease, Settore MED/09 - Medicina Interna |
| الوصف: | Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport. Iron homeostasis is balanced by the interplay of proteins responsible for iron import, storage, and export. A misbalance of iron homeostasis may cause either iron deficiencies or iron overload diseases. The clinical work-up of iron dysregulation is highly important, as severe symptoms and pathologies may arise. Treating iron overload or iron deficiency is important to avoid cellular damage and severe symptoms and improve patient outcomes. The impressive progress made in the past years in understanding mechanisms that maintain iron homeostasis has already changed clinical practice for treating iron-related diseases and is expected to improve patient management even further in the future. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36986429; info:eu-repo/semantics/altIdentifier/wos/WOS:000958875000001; volume:16; issue:3; firstpage:1; lastpage:19; numberofpages:19; journal:PHARMACEUTICALS; https://hdl.handle.net/2434/968073; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85152434553 |
| DOI: | 10.3390/ph16030329 |
| الاتاحة: | https://hdl.handle.net/2434/968073 https://doi.org/10.3390/ph16030329 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AE01EE86 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ph16030329 |
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