Academic Journal
Glycosaminoglycans, protein aggregation and neurodegeneration.
| العنوان: | Glycosaminoglycans, protein aggregation and neurodegeneration. |
|---|---|
| المؤلفون: | Papy-Garcia, Dulce, Christophe, Morin, Huynh, Minh Bao, Fernando, Sineriz, Ludmilla, Sissoeff, Sepulveda-Diaz, Julia Elisa, Raisman-Vozari, Rita |
| المساهمون: | Croissance cellulaire, réparation et régénération tissulaires (CRRET), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), fernando.soria@uam.es, Departamento de Matematicas (UAM), Universidad Autónoma de Madrid (UAM)-Universidad Autónoma de Madrid (UAM), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1389-2037 ; Current Protein and Peptide Science ; https://hal.science/hal-01588263 ; Current Protein and Peptide Science, 2011, pp.258-68. |
| بيانات النشر: | CCSD Bentham Science Publishers |
| سنة النشر: | 2011 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | MESH: Amyloid beta-Peptides, MESH: Glycosaminoglycans, MESH: alpha-Synuclein, MESH: Humans, MESH: Membrane Proteins, MESH: Neurodegenerative Diseases, MESH: Peptide Fragments, MESH: Prion Diseases, MESH: Prions, MESH: Protein Conformation, MESH: Proteins, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication |
| الوصف: | International audience ; A number of neurodegenerative diseases, as Parkinson, prion, and Alzheimer's diseases, has been directly associated with altered conformations of certain peptides or proteins that assemble to form highly organized aggregates, also called amyloid fibers. Glycosaminoglycans have shown to play important roles on fibrils formation, stability and resistance to proteolysis. This manuscript reviews from basic concepts on the biochemistry and biology of glycosaminoglycans to their implications in neurodegeneration with particular emphasis in pathologic protein aggregation. Prion protein, Aβ42, Tau, and α-synuclein, are all proteins that can interact with glycosaminoglycans. We document here how these interactions may modify protein conformation, aggregation kinetics, and fibers stabilization with important consequences in disease. We also raise questions which answers may make advance the understanding of the implication of GAGs in neurodegeneration. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/21348835; PUBMED: 21348835 |
| الاتاحة: | https://hal.science/hal-01588263 |
| رقم الانضمام: | edsbas.AE00FC57 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |