Academic Journal
Does equipment change impact blood contamination with irinotecan and its two major metabolites in a centralized cytotoxic pharmacy unit?
| العنوان: | Does equipment change impact blood contamination with irinotecan and its two major metabolites in a centralized cytotoxic pharmacy unit? |
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| المؤلفون: | Benoist, H, Breuil, C, Le Neindre, B, Delépée, R, Saint-Lorant, G |
| المصدر: | Journal of Oncology Pharmacy Practice ; volume 26, issue 8, page 1823-1828 ; ISSN 1078-1552 1477-092X |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2020 |
| الوصف: | Background Antineoplastic drugs exposure is a major problem for caregivers’ health. The aim of this study is to assess blood contamination with irinotecan and its two metabolites in a centralized pharmacy unit for cytotoxic drug preparations workers before and after protective equipment changes. Methods The study took place in a university hospital centralized pharmacy unit for cytotoxic drug and was performed in two parts, before (Round 1: R1) and after equipment changes (Round 2: R2). Collection of pharmacy staff blood samples was performed in UHPLC-MS/MS. Plasma and red blood cell irinotecan and its metabolites (SN38; APC) were determined with a validated analytical method detection test. Results A total of 15/36 (41.6%) assays were positive in R1 and 16/72 (22.2%) in R2 with a significant decrease between periods ( P = 0.035). For plasma dosages, no difference between the two periods was found ( P = 0.71); respectively 4/18 (22.2%) assays were positive in R1 and 6/36 (16.6%) in R2. For red blood cells dosages, a significant decrease between periods was found ( P = 0.01); respectively 11/18 (61%) were positive in R1 and 10/36 (27.8%) in R2. Conclusions These dosages make it possible to have the very first evaluation for plasma and red blood cell contamination with irinotecan and its metabolites in the context of equipment changes, both at individual and collective levels. This work would help to protect health workers from the potential risks represented by these molecules, especially by revealing a contamination of workers in order to objectify the results of exposure. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/1078155220905013 |
| الاتاحة: | https://doi.org/10.1177/1078155220905013 https://journals.sagepub.com/doi/pdf/10.1177/1078155220905013 https://journals.sagepub.com/doi/full-xml/10.1177/1078155220905013 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.ADFDADFD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1078155220905013 |
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