Academic Journal
MYD88 Mutations: Transforming the Landscape of IgM Monoclonal Gammopathies
| العنوان: | MYD88 Mutations: Transforming the Landscape of IgM Monoclonal Gammopathies |
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| المؤلفون: | Alcoceba, Miguel, García-Alvarez, María, Medina, Alejandro, Maldonado, Rebeca, González-Calle, Verónica, Chillón, M. del Carmen, Sarasquete, María Eugenia, González, Marcos, García-Sanz, Ramón, Jiménez, Cristina |
| المساهمون: | Instituto de Salud Carlos III, European Commission, Ministerio de Economía y Competitividad (España) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2022 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Signal transduction, Hematologic neoplasms, Targeted therapy, Waldenström’s macroglobulinemia |
| الوصف: | The MYD88 gene has a physiological role in the innate immune system. Somatic mutations in MYD88, including the most common L265P, have been associated with the development of certain types of lymphoma. MYD88L265P is present in more than 90% of patients with Waldenström’s macroglobulinemia (WM) and IgM monoclonal gammopathy of undetermined significance (IgM-MGUS). The absence of MYD88 mutations in WM patients has been associated with a higher risk of transformation into aggressive lymphoma, resistance to certain therapies (BTK inhibitors), and shorter overall survival. The MyD88 signaling pathway has also been used as a target for specific therapies. In this review, we summarize the clinical applications of MYD88 testing in the diagnosis, prognosis, follow-up, and treatment of patients. Although MYD88L265P is not specific to WM, few tumors present a single causative mutation in a recurrent position. The role of the oncogene in the pathogenesis of WM is still unclear, especially considering that the mutation can be found in normal B cells of patients, as recently reported. This may have important implications for early lymphoma detection in healthy elderly individuals and for the treatment response assessment based on a MYD88L265P analysis. ; This study was funded by the Instituto de Salud Carlos III through the projects PI18/01866 and PI22/00568 (co-funded by the European Union: European Regional Development Fund/European Social Fund “A way to make Europe”/“Investing in your future”), the Spanish Ministry of Economy and Competitiveness CIBERONC-CB16/12/00233, and “Una manera de hacer Europa” (Innocampus; CEI-2010-1-0010)”. C.J. was supported by the Instituto de Salud Carlos III (Contrato Sara Borrell CD19/00030). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| تدمد: | 1661-6596 |
| Relation: | Publisher's version; http://dx.doi.org/10.3390/ijms23105570; Sí; e-issn: 1422-0067; International Journal of Molecular Sciences 23(10): 5570 (2022); http://hdl.handle.net/10261/282991; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/501100004587; http://dx.doi.org/10.13039/501100003329 |
| DOI: | 10.3390/ijms23105570 |
| DOI: | 10.13039/501100000780 |
| DOI: | 10.13039/501100004587 |
| DOI: | 10.13039/501100003329 |
| الاتاحة: | http://hdl.handle.net/10261/282991 https://doi.org/10.3390/ijms23105570 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100004587 https://doi.org/10.13039/501100003329 |
| Rights: | open |
| رقم الانضمام: | edsbas.ADDD2ECF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16616596 |
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| DOI: | 10.3390/ijms23105570 |