التفاصيل البيبلوغرافية
| العنوان: |
Interstitial Lung Fibrosis Following COVID-19 Pneumonia |
| المؤلفون: |
Mihai Lazar, Ecaterina Constanta Barbu, Cristina Emilia Chitu, Catalin Tiliscan, Laurentiu Stratan, Sorin Stefan Arama, Victoria Arama, Daniela Adriana Ion |
| المصدر: |
Diagnostics; Volume 12; Issue 8; Pages: 2028 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
pulmonary fibrosis, SARS-COV-2, long COVID, risk factors, fibrosis predictors, quantitative analysis |
| الوصف: |
Background and Objectives: Pulmonary fibrosis represents a stage of normal physiologic response to inflammatory aggression, mostly self-limiting and reversible; however, numerous patients treated for SARS-CoV-2 pneumonia present after release from hospital residual lung fibrosis. In this article, we aim to present an optimization method for evaluating pulmonary fibrosis by quantitative analysis, to identify the risk factors/predictors for pulmonary fibrosis in patients with SARS-CoV-2 infection, and to characterize the impact of pulmonary fibrosis on the symptomatology of patients after release from the hospital. Materials and Methods: We performed a prospective observational study on 100 patients with severe forms of pneumonia, with a control group of 61 non-COVID normal patients. Results: We found persistent interstitial changes consistent with fibrotic changes in 69% of patients. The risk of fibrosis was proportional to the values of erythrocyte sedimentation rate (ESR), C reactive protein (CRP), and lactate dehydrogenase (LDH), and to the duration of hospitalization. The imaging parameters correlated with increased risk for interstitial fibrosis were the number of affected pulmonary lobes and the percent of interstitial pulmonary fibrosis. Conclusions: The main risk factors for pulmonary fibrosis post-COVID-19 identified in our study are increased ESR, CRP, LDH, duration of hospitalization and the severity of pneumonia. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Point-of-Care Diagnostics and Devices; https://dx.doi.org/10.3390/diagnostics12082028 |
| DOI: |
10.3390/diagnostics12082028 |
| الاتاحة: |
https://doi.org/10.3390/diagnostics12082028 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.AD8BE10B |
| قاعدة البيانات: |
BASE |