التفاصيل البيبلوغرافية
| العنوان: |
Vivax malaria in Mauritania includes infection of a Duffy-negative individual |
| المؤلفون: |
Wurtz, N., Lekweiry, K. M., Bogreau, H., Pradines, B., Rogier, C., Ould Mohamed Salem Boukhary, A.S., Hafid, J. E., Ould Ahmedou Salem, M.S., /Trape, Jean-François, /Basco, Leonardo, Briolant, S. |
| سنة النشر: |
2011 |
| المجموعة: |
IRD (Institute de recherche pour le développement): Horizon |
| مصطلحات موضوعية: |
Plasmodium vivax, Duffy blood group, Mauritania, polymorphism, malaria |
| الوصف: |
Background: Duffy blood group polymorphisms are important in areas where Plasmodium vivax is present because this surface antigen is thought to act as a key receptor for this parasite. In the present study, Duffy blood group genotyping was performed in febrile uninfected and P. vivax-infected patients living in the city of Nouakchott, Mauritania. Methods: Plasmodium vivax was identified by real-time PCR. The Duffy blood group genotypes were determined by standard PCR followed by sequencing of the promoter region and exon 2 of the Duffy gene in 277 febrile individuals. Fisher's exact test was performed in order to assess the significance of variables. Results: In the Moorish population, a high frequency of the FYBES/FYBES genotype was observed in uninfected individuals (27.8%), whereas no P. vivax-infected patient had this genotype. This was followed by a high level of FYA/FYB, FYB/FYB, FYB/FYBES and FYA/FYBES genotype frequencies, both in the P. vivax-infected and uninfected patients. In other ethnic groups (Poular, Soninke, Wolof), only the FYBES/FYBES genotype was found in uninfected patients, whereas the FYA/FYBES genotype was observed in two P. vivax-infected patients. In addition, one patient belonging to the Wolof ethnic group presented the FYBES/FYBES genotype and was infected by P. vivax. Conclusions: This study presents the Duffy blood group polymorphisms in Nouakchott City and demonstrates that in Mauritania, P. vivax is able to infect Duffy-negative patients. Further studies are necessary to identify the process that enables this Duffy-independent P. vivax invasion of human red blood cells. |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| Relation: |
https://www.documentation.ird.fr/hor/fdi:010054220; oai:ird.fr:fdi:010054220; Wurtz N., Lekweiry K. M., Bogreau H., Pradines B., Rogier C., Ould Mohamed Salem Boukhary A.S., Hafid J. E., Ould Ahmedou Salem M.S., Trape Jean-François, Basco Leonardo, Briolant S. Vivax malaria in Mauritania includes infection of a Duffy-negative individual. 2011, 10, p. 336 |
| الاتاحة: |
https://www.documentation.ird.fr/hor/fdi:010054220 |
| رقم الانضمام: |
edsbas.AD3EAD58 |
| قاعدة البيانات: |
BASE |