Academic Journal
Bisphenol A affects neural development of the ascidian Ciona robusta
| العنوان: | Bisphenol A affects neural development of the ascidian Ciona robusta |
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| المؤلفون: | Messinetti, Silvia, Mercurio, Silvia, Pennati, Roberta |
| المصدر: | Journal of Experimental Zoology Part A: Ecological and Integrative Physiology ; volume 331, issue 1, page 5-16 ; ISSN 2471-5638 2471-5646 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2018 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Bisphenol A (BPA) is an organic pollutant derived from plastic degradation that has numerous and variable adverse effects on human health and wildlife. In particular, it has been reported that BPA can alter reproductive processes and nervous system development in vertebrates. Considering BPA presence in marine environment and the scant data available on its interaction with nervous system development, we analyzed the effect of BPA exposure on sperm viability, fertilization, embryogenesis, and neural differentiation of the ascidian Ciona robusta . Ascidians are members of the Phylum Tunicata, the sister group of Vertebrata, sharing with them fundamental developmental processes. Our results showed that first cell division was altered starting from 5 µM concentration. Lethal concentration (LC 50 ) was estimated to be 5.2 µM. Larvae developed from treated embryos showed specific malformations to the pigment cells even at 0.1 µM, corresponding to the highest environmental concentration reported so far. Moreover, GABAergic and dopaminergic neurons proved to be target organs of BPA teratogenic action, in accordance with similar results reported in vertebrate animal models. Overall, our results suggest that BPA can exert its effects on nervous system acting on different pathways and underline that C. robusta is a valuable invertebrate animal model for preliminary screenings of effects of pollutants on vertebrates. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/jez.2230 |
| الاتاحة: | http://dx.doi.org/10.1002/jez.2230 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjez.2230 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jez.2230 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.AD391880 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jez.2230 |
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