Academic Journal
Maternal factors modulate the increase in vasoactive substances during rat pregnancy
| العنوان: | Maternal factors modulate the increase in vasoactive substances during rat pregnancy |
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| المؤلفون: | Giacaman, A, Salas, SP, Rosso, P |
| بيانات النشر: | MARCEL DEKKER INC |
| سنة النشر: | 2024 |
| المجموعة: | Pontificia Universidad Católica de Chile: Repositorio UC |
| مصطلحات موضوعية: | pseudopregnancy, ovarian steroids, prostaglandins, urinary kallikrein activity, cGMP, rats, NITRIC-OXIDE SYNTHESIS, ATRIAL NATRIURETIC FACTOR, PLASMA-VOLUME EXPANSION, URINARY-EXCRETION, BLOOD-PRESSURE, CARDIAC-OUTPUT, RENAL-FUNCTION, FETAL GROWTH, ALDOSTERONE, PROGESTERONE, 05 Gender Equality, 03 Good Health and Well-being, 05 Igualdad de género, 03 Salud y bienestar |
| الوصف: | Objective: To explore if the changes in vasoactive substances observed during early pregnancy in the rat are modulated by maternal or fetoplacental factors. ; Methods: Urinary excretion of cGMP, 6-keto-prostagladin-F1 alpha (6-keto-PGF1 alpha), thromboxane B-2 and kallikrein activity was measured in pregnant (P, n = 11), pseudopregnant (PSP, n = 12), and virgin (n = 13) rats and in ovariectomized virgin rats supplemented with slow-release pellets containing either progesterone (50 mg/pellet) or estradiol (0.5 mg/pellet) or a combination of both hormones, for 21 days. ; Results: The cGMP excretion was higher in PSP rats than in virgin rats at day 5 (virgin = 82 +/- 7, P = 93 +/- 5, PSP = 110 +/- 8 nmol/24 h, p < 0.05); at day 10, values were significantly increased in P and PSP rats. 6-keto-PGF1 alpha excretion was similarly elevated in P and PSP rats at day 5 (virgin = 120 +/- LO, P = 160 +/- 10, and PSP = 174 +/- 14 ng/24 h, p < 0.01). This trend was still present at day 10. Thromboxane B-2 excretion showed a nonsignificant increase in P and PSP rats in day 5; at: day 10, values were significantly elevated in both experimental groups (virgin = 23 +/- 2, P = 32 +/- 4, and PSP = 32 +/- 2 ng/24 h, p < 0.05). Kallikrein excretion was significantly increased in PSP and P rats at days 5 and 10. Estradiol or progesterone administration caused a significant decrease in serum aldosterone and an increase in urinary kallikrein activity. ; Conclusions: These results indicate that during the first half of rat pregnancy, the increment in vasoactive substances is modulated by maternal and not by fetoplacental factors. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 12 páginas; application/pdf |
| اللغة: | English |
| تدمد: | 1064-1955 |
| Relation: | MEDLINE:10463997; https://doi.org/10.3109/10641959909009608; https://repositorio.uc.cl/handle/11534/79523; WOS:000079425300003 |
| DOI: | 10.3109/10641959909009608 |
| الاتاحة: | https://repositorio.uc.cl/handle/11534/79523 https://doi.org/10.3109/10641959909009608 |
| Rights: | acceso restringido |
| رقم الانضمام: | edsbas.AD36617F |
| قاعدة البيانات: | BASE |
| تدمد: | 10641955 |
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| DOI: | 10.3109/10641959909009608 |