Academic Journal
Hepatic lead and copper concentrations in dogs with chronic hepatitis and their relationship with hematology, serum biochemistry, and histopathology
| العنوان: | Hepatic lead and copper concentrations in dogs with chronic hepatitis and their relationship with hematology, serum biochemistry, and histopathology |
|---|---|
| المؤلفون: | Gori, Eleonora, Pierini, Alessio, Meucci, Valentina, Abramo, Francesca, Muscatello, Luisa V., Marchetti, Veronica |
| المصدر: | Journal of Veterinary Internal Medicine ; volume 35, issue 4, page 1773-1779 ; ISSN 0891-6640 1939-1676 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Although the influence of copper ([Cu]) on chronic hepatitis (CH) has been widely studied in dogs, little information is available about the accumulation of other metals. Hypothesis/Objectives We assessed the concentration of lead ([Pb]) in the livers of dogs with CH with or without abnormal hepatic [Cu] to establish if any association existed between [Pb] and either hematologic or biochemical variables, fibrosis, necrosis and inflammation of the liver on histology. Animals Thirty‐four dogs with CH that had hepatic [Cu] and [Pb] determined. Methods Retrospective review of medical records of dogs with CH and hepatic [Cu] and [Pb]. Chronic hepatitis was defined using current American College of Veterinary Internal Medicine consensus statement guidelines. Hepatic [Cu] and [Pb] were determined using square wave anodic stripping voltammetry. Dogs were divided into 2 groups based on [Cu]: <400 ppm (LoCu) and ≥400 ppm (HiCu). Results The median [Cu] and [Pb] were 357 ppm (range, 100‐7743 ppm) and 58.7 (range, 6.89‐224.4 ppm), respectively. Nineteen dogs had LoCu and 15 dogs had HiCu. Median [Pb] was significantly higher in HiCu compared to LoCu dogs ( P < .001). Hepatic [Pb] and [Cu] were significantly correlated (rho = 0.7; P < .001). Dogs with microcytosis had higher [Pb] than did dogs with normal red cell volume ( P = .02). Hepatic [Pb] was not correlated with either necroinflammatory or fibrosis scores. Conclusions and Clinical Importance Although additional studies are needed to better understand the clinical role of hepatic [Pb], dogs with abnormal hepatic [Cu] may also have higher hepatic [Pb]. In addition, in dogs with high hepatic [Pb], microcytosis may be present. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/jvim.16149 |
| الاتاحة: | http://dx.doi.org/10.1111/jvim.16149 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jvim.16149 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jvim.16149 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.AD2C2B8A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/jvim.16149 |
|---|